Novel Palmitoyl Pentapeptides: Self-Assembly, Collagen Stimulation, Antioxidant Activity, and Influence of Skin Microbiota Health pubmed.ncbi.nlm.nih.gov/41970822/ #cryoEM

Structural basis for allosteric regulation of mycobacterial guanosine 5´-monophosphate reductase by ATP and GTP pubmed.ncbi.nlm.nih.gov/41974687/ #cryoEM

A short story of the long road to cryo-EM in Portugal pubmed.ncbi.nlm.nih.gov/41973445/ #cryoEM

Cryo-Electron Tomography Workflow for Thick Tissues Demonstrated in Mouse Hippocampus pubmed.ncbi.nlm.nih.gov/41973628/ #cryoEM

1/ Excited to share our preprint! 🥳

Degradation of aromatic compounds, including BTEX pollutants, requires highly endergonic aromatic ring reduction. Using #cryoEM and in situ #cryoET, we show how BCRII couples electron bifurcation modules in one giant redox machine

www.biorxiv.org/content/10.6...

Decoding Outer Membrane β-Barrels: From Structural Curiosity to Engineered Nanotherapeutics pubmed.ncbi.nlm.nih.gov/41973831/ #cryoEM

#cryosky crowd: for a project we are looking for Quantifoil R0.6/1 copper grids that are currently unavailable from the manufacturer. If anybody has any stock to spare, please let me know! #cryoEM

Structural atlas of the intact jumbo phage phiKZ pubmed.ncbi.nlm.nih.gov/41974715/ #cryoEM

Development of a thermosensitive hydrogel containing liposomes for sustained dexamethasone delivery in sensorineural hearing loss pubmed.ncbi.nlm.nih.gov/41966427/ #cryoEM

HECT-Type Ubiquitin Ligases: Emerging principles in the Era of Full-Length Structures pubmed.ncbi.nlm.nih.gov/41966274/ #cryoEM

Single amino acid substitutions modulate the function of α9α10 nicotinic acetylcholine receptor pubmed.ncbi.nlm.nih.gov/41966377/ #cryoEM

Structural cartoon models of human S1PR1 in complex with Gi1, scFv16, and each of the four agonists: CYM5442, HY-X-1011, Ponesimod, or SAR247799. S1PR1 is colored marine, Gαi1 pale green, Gβ1 light blue, Gγ2 wheat, scFv16 gray, and agonists yellow.

#Sphingosine -1-phosphate receptors #S1PRs play complex roles in several pathological processes. #CryoEM structures of four agonist-bound S1PR1-Gi1 complexes reveal the structural determinants underlying agonist selectivity among different subtypes @plosbiology.org 🧪 plos.io/4co0A4W

Now available - The Nanosoft 8-Pocket Autogrid Box - A #cryoem grid box with 8 pockets designed, shaped & sized for autogrids - Pockets are offset to make autogrid removal easier - Available in 6 colors & with a random, unique 5-digit serial number -> zurl.co/89dEH

Microglia-Specific K2P Channel THIK-1: Structure, Function, and Therapeutic Potential pubmed.ncbi.nlm.nih.gov/41968284/ #cryoEM

Structural cartoon models of human S1PR1 in complex with Gi1, scFv16, and each of the four agonists: CYM5442, HY-X-1011, Ponesimod, or SAR247799. S1PR1 is colored marine, Gαi1 pale green, Gβ1 light blue, Gγ2 wheat, scFv16 gray, and agonists yellow.

#Sphingosine -1-phosphate receptors #S1PRs play complex roles in several pathological processes. #CryoEM structures of four agonist-bound S1PR1-Gi1 complexes reveal the structural determinants underlying agonist selectivity among different subtypes @plosbiology.org 🧪 plos.io/4co0A4W

📣Please check out our latest preprint on the #structure, stability and specificity of the type II secretion pilus. #nmr #cryoEM
Great collab with the teams of @oliverafr.bsky.social Nilges @pasteur.fr @ipdbsc.bsky.social @cnrsbiologie.bsky.social
Egelman, Shevchik
www.biorxiv.org/content/10.6...

Here you can see a cryoEM structure of DNA-PK kinase inside the NHEJ complex (PDB code: 7LT3)

Rendering by Francisco J. Enguita made with #ProteinImager

3dproteinimaging.com/protein-imag...

#SciArt #molecularart #dna #repair #kinase #cryoem #nhej

Structural determinants of endopilus assembly, stability and functional specificity in bacterial type II secretion www.biorxiv.org/content/10.64898/2026.04.10.717868v1 #cryoEM

Structural cartoon models of human S1PR1 in complex with Gi1, scFv16, and each of the four agonists: CYM5442, HY-X-1011, Ponesimod, or SAR247799. S1PR1 is colored marine, Gαi1 pale green, Gβ1 light blue, Gγ2 wheat, scFv16 gray, and agonists yellow.

#Sphingosine -1-phosphate receptors #S1PRs play complex roles in several pathological processes. #CryoEM structures of four agonist-bound S1PR1-Gi1 complexes reveal the structural determinants underlying agonist selectivity among different subtypes @plosbiology.org 🧪 plos.io/4co0A4W

Mechanism of GPR84 allosteric modulation at a helix 8-proximate site www.biorxiv.org/content/10.64898/2026.04.10.715585v1 #cryoEM

Unraveling the complexities of the Borna disease virus 1 Kyoto, Japan -- Cases of Borna disease virus 1, or BoDV-1, are extremely rare in humans, but in those who develop disease the outcome is severe, almost always resulting in fatal encephalitis or inflam...

English press release (Kyoto University):
www.kyoto-u.ac.jp/en/research-...

#Virology #CryoEM

Updated: peer-reviewed paper is now out in #ScienceAdvances. We report the first high-res #cryoEM structure of Borna disease virus 1 nucleoprotein-RNA complex in the family Bornaviridae. Collaborative work with Dr. Hirai, Dr. Horie @mhorieomu.bsky.social et al.

www.science.org/doi/10.1126/...

An RNA-to-RNA Pipeline for Rapid Antiviral Antibody Development pubmed.ncbi.nlm.nih.gov/41964219/ #cryoEM

A brain-penetrant P2X7R antagonist mitigates Alzheimer’s disease pathology www.biorxiv.org/content/10.64898/2026.04.06.716621v1 #cryoem

Learning latent conformational landscapes encoded in cryo-EM www.biorxiv.org/content/10.64898/2026.04.10.717737v1 #cryoEM

The Central Coupler of the AAA+ ATPase ClpXP Controls Intersubunit Communication and Couples the Conversion of Chemical Energy into the Generation of Force www.biorxiv.org/content/10.64898/2026.04.10.717754v1 #cryoEM

Cryo-EM structures of a neofunctionalized tardigrade peroxiredoxin specialized for nucleic acid binding www.biorxiv.org/content/10.64898/2026.04.10.717662v1 #cryoEM

MVGFormer: Multi-view perspective with graph-guided transformer for cryo-ET segmentation pubmed.ncbi.nlm.nih.gov/41959693/ #cryoEM

Homo-epitaxy and twinning produce complex nanostructures in cryogenic calcite pubmed.ncbi.nlm.nih.gov/41959867/ #cryoEM

Quantum refinement with electron diffraction and X-ray free-electron laser data: comparative study of ribonucleotide reductase dimetal site pubmed.ncbi.nlm.nih.gov/41959874/ #cryoEM