Here you can see a cryoEM structure of DNA-PK kinase inside the NHEJ complex (PDB code: 7LT3)
Rendering by Francisco J. Enguita made with #ProteinImager
3dproteinimaging.com/protein-imag...
#SciArt #molecularart #dna #repair #kinase #cryoem #nhej
Here you can see a cryoEM structure of the human NHEJ Long-range synaptic complex (PDB code: 7LT3)
Rendering by Francisco J. Enguita made with #ProteinImager
#SciArt #molecularart #cryoem #NHEJ #complex #DNArepair #joining
REVIEW: Nonhomologous end joining—the importance of end tethering and beyond
By Shan Zha and Geunil Yi
➡️ https://genesdev.cshlp.org/content/40/7-8/411.full
Columbia University
#DNArepair #NHEJ #KuProtein #proteininteractions
🐯 BREAKTHROUGH: #TIGER platform corrects frameshift #mutations WITHOUT donor templates
🧬 Harnesses predictable #NHEJ repair patterns
📊 AI algorithm predicts editing outcomes
🦻 Restores hearing in deaf mice (12-month durability)
⚡ 30× more efficient than prime editing
doi.org/10.1038/s415...
✂️🪲Injection-based insect genome editing: fusing a HUH endonuclease tag to #Cas9 boosts both #NHEJ ‑driven knockout and HDR‑mediated #knock‑in across multiple arthropods.
www.nature.com/articles/s42...
Novel molecular assays for monitoring T cell function after HSCT in two siblings with variants in DCLRE1C. New study from Anna Lyytikäinen, Pegah Johansson and colleagues (Sahlgrenska University Hospital): rupress.org/jhi/article/...
#SCID #CellDivisionAssay #FlowCytometry #DNARepair #DSB #NHEJ
Mechanistic insights into how the dynamic conversion of Ku80 K568 PTM from crotonylation to #SUMOylation regulates DNA-PK complex & #NHEJ initiation to promote DNA double-strand break repair and tumor #Radioresistance. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
When you have to stay home sick in this household, you get treated to a webinar on DNA repair at lunch time. Lucky kiddo. #NHEJ
(3/n) I was lucky to have an excellent PhD supervisor in @dale_ramsden at @UNC_Lineberger. Not only did Dale become an @Addgene depositor (https://www.addgene.org/Dale_Ramsden/ but he and his grad student David Wyatt wrote this great Addgene blog post on #NHEJ:...
