Fabulous work by Aimiliani Konstantinou, together with three other #UBIMOTIF members Alicia Córdova-Pérez, Julia K. Varga & Maximilian Vieler. #CYLD, #USP7, #USP11, #USP20, #USP22, #USP33

A mechanism for hypoxia-induced inflammatory cell death in cancer - Nature We find that PTP1B and ABL1/2 reciprocally control RNF213 tyrosine phosphorylation and its oligomerization and RZ domain activation, and identify a unique PTP1B–RNF213–CYLD–SPATA2 pathway critical for...

this week #JournalClub @labsoap.bsky.social #CYLD #SPATA2 #ubiquitination #dUB #Phosphatase #hypoxia @nature.com www.nature.com/articles/s41...