A mechanism for hypoxia-induced inflammatory cell death in cancer - Nature We find that PTP1B and ABL1/2 reciprocally control RNF213 tyrosine phosphorylation and its oligomerization and RZ domain activation, and identify a unique PTP1B–RNF213–CYLD–SPATA2 pathway critical for...

this week #JournalClub @labsoap.bsky.social #CYLD #SPATA2 #ubiquitination #dUB #Phosphatase #hypoxia @nature.com www.nature.com/articles/s41...