Admin got up yesterday at 7 in the morning to perform a transformation that probably didn't work. One (1) colony on the plates. This is the #chembiosky life.
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![Scientific illustration depicting the design and control of protein folding and stability. The left side shows a progression from amino acid sequence rules to peptide helices (colored cylinders with directional arrows), which assemble into structured proteins. The right side features two graphs labeled "Control": the top graph plots fraction folded (θ) versus temperature (°C) with multiple colored curves, and the bottom graph shows a linear decrease in melting temperature (Tm) with increasing guanidinium hydrochloride concentration ([GdmHCl]). A yellow circle labeled "PICK OF THE WEEK" appears in the bottom left corner.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:ztf52qr22zoguidj6uprs6az/bafkreidxgvsnnj6sbji64ddz4b3i2z2jlgxbaymmibuvbeoq4dub62ozym)
Scientific illustration depicting the design and control of protein folding and stability. The left side shows a progression from amino acid sequence rules to peptide helices (colored cylinders with directional arrows), which assemble into structured proteins. The right side features two graphs labeled "Control": the top graph plots fraction folded (θ) versus temperature (°C) with multiple colored curves, and the bottom graph shows a linear decrease in melting temperature (Tm) with increasing guanidinium hydrochloride concentration ([GdmHCl]). A yellow circle labeled "PICK OF THE WEEK" appears in the bottom left corner.
Our Chemical Science Pick of the Week is from Dek Woolfson and colleagues!
"De novo designed 3-helix bundle peptides and proteins with controlled topology and stability"
Read for free here: doi.org/10.1039/D5SC...
#ChemSky #ChemBioSky 🧪
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Something big is coming…
Soon, we’ll be able to share a story of peptide helicates, helical polymers, and DNA junctions.
Stay tuned 😉
#ChemSky #DNAJunctions #SupraChemSky #ChemBioSky
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Call for Expressions of Interest – MSCA Postdocs 2025
Join my group at CiQUS to work on “Selective DNA Junction Binders for Targeted Anticancer Therapy”.
Deadline: June 15
www.usc.es/ciqus/en/MSC...
#MSCA #CiQUS #DNAJunctions #Postdoc #ChemSky #ChemBioSky
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Nice video and gorgeous crystal structure, Christine. I love it and I love the original paper too #DNAJunctions #IRN_NAC #ChemSky #ChemBioSky
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Can’t wait to travel to Pavia next month to see my friends.
Honored to speak at the Università di Pavia about our latest work on peptide helicates and DNA three-way junctions.
#DNAJunctions #ChemSky #ChemBioSky
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Inspiring morning at @ciqus.bsky.social with @lsalassa.bsky.social, who showed how flavin photocatalysis can unlock new paths for platinum-based cancer therapies. Brilliant chemistry 🧪, sharp vision 💡
#chemsky #chembiosky
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PhD opportunity available in my lab @edinuni-irr.bsky.social and @edinburghchem.bsky.social. Developing chemical tools for Ubiquitin-like proteins. 3.5 years and would be a good fit for a molecular sciences (chem/bio) background. tinyurl.com/5h5xz93r
#chembiosky
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Great to have Prof. Xiaoguang Lei of Peking University at FU Berlin for his talk, “Opportunities for Merging Chemical and Biological Synthesis”! #ChemicalBiology #Synthesis #ChemBioSky
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Fantastic talk, ‘Organic Chemistry to Shine Light on Biology,’ by Johannes Broichhagen (@broichhagenj.bsky.social) from the Forschungsinstitut für Molekulare Pharmakologie (FMP) in Berlin. For a comprehensive overview of his work, check out: doi.org/10.1002/anie... #ChemSky #ChemBioSky
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Well, so much for the fraternal banter.
#chembiosky vs #nanosky
The fight for #chemsky is on
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Come on #chembiosky we need to try and push the RSC Chemical Biology group @rsc-cbbg.bsky.social follower count above the Nanoscience group!!!!
#chemsky 🧪
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