Unveiling BCL-xL-specific PROTAC efficiency and dissociation pathways using native mass spectrometry Overexpression of anti-apoptotic proteins such as BCL-xL is a hallmark of various cancers and a major driver of resistance to conventional chemotherapies. While small-molecule BCL-xL inhibitors have s...

Unveiling BCL-xL-specific PROTAC efficiency and dissociation pathways using native mass spectrometry #ChemSci pubs.rsc.org/en/content/a...

Exposure single-cell metabolomics mass spectrometry reveals HFPO-DA toxicity mechanisms Hexafluoropropylene oxide-dimer acid (HFPO-DA) is widely used in food packaging bags, surfactants, lubricants, etc. As a new substitute for the persistent organic pollutant perfluorooctanoic acid (PFO...

Exposure single-cell metabolomics mass spectrometry reveals HFPO-DA toxicity mechanisms #ChemSci pubs.rsc.org/en/content/a...

Single-cell structural lipidomics using a miniature dual-LIT mass spectrometer Structural lipidomics provides comprehensive information on lipidomes, and there is great interest in applying it to single-cell analysis for accurate cell phenotyping and lipid pathway studies. Howev...

Single-cell structural lipidomics using a miniature dual-LIT mass spectrometer #ChemSci pubs.rsc.org/en/content/a...

Single-cell metabolic accumulation analysis by microfluidic hydrogel microspheres combined with mass spectrometry Metabolic analysis of tumor cells is crucial for understanding tumor metabolic reprogramming, and single-cell metabolic accumulation studies provide precise insights into tumor biology. In this work, ...

Single-cell metabolic accumulation analysis by microfluidic hydrogel microspheres combined with mass spectrometry #ChemSci #MassSpec pubs.rsc.org/en/content/a...

A high-throughput N-glycan analysis strategy with targeted mass spectrometry (HTnGQs-target) for liver disease diagnosis Hepatocellular carcinoma (HCC), a global leading cause of cancer-related mortality, is critically hindered by delayed diagnosis due to the lack of sensitive early biomarkers. Alterations in N-glycan c...

A high-throughput N-glycan analysis strategy with targeted mass spectrometry (HTnGQs-target) for liver disease diagnosis #ChemSci pubs.rsc.org/en/content/a...

Mass spectrometry detects folding intermediates populated during urea-induced protein denaturation Protein folding stability can be probed using urea, a chaotropic agent that disrupts non-covalent interactions at molar concentrations. The denaturation process is typically monitored via optical spec...

Mass spectrometry detects folding intermediates populated during urea-induced protein denaturation #ChemSci pubs.rsc.org/en/content/a...

Detection of single-cell enzyme activity by single-time-point stable isotope probing-mass spectrometry Elucidation of single-cell enzyme activity is essential for clarifying cellular heterogeneity and its causal relationship with cell fate. In the currently available methods for enzyme activity detecti...

Detection of single-cell enzyme activity by single-time-point stable isotope probing-mass spectrometry #ChemSci pubs.rsc.org/en/content/a...

Multi-region mapping of ligand binding and structural changes in the β-1 adrenergic receptor using carbene footprinting and mass spectrometry G protein-coupled receptors (GPCRs) control many physiological processes and are major targets for therapeutic intervention. Transmembrane proteins, such as GPCRs, are inherently flexible and dynamic ...

Multi-region mapping of ligand binding and structural changes in the β-1 adrenergic receptor using carbene footprinting and mass spectrometry #ChemSci pubs.rsc.org/en/content/a...

Chemoselective cyclodesulfurization vs. dehydration enabled by aqueous microdroplet chemistry Dehydration reactions are typically favored in microdroplets due to the relatively dry environment at the air–water interface. However, we demonstrate that cyclodesulfurization may outcompete dehydrat...

Chemoselective cyclodesulfurization vs. dehydration enabled by aqueous microdroplet chemistry #ChemSci #MassSpec pubs.rsc.org/en/content/a...

Unveiling leaching–oxidizing–landing paths of Pd single-atom catalyzed Suzuki–Miyaura reaction by ambient mass spectrometry The palladium-catalyzed Suzuki–Miyaura cross-coupling (SMCC) reaction is an essential technique for C–C bond formation. It is considered to occur through two distinct pathways involving homogeneous an...

Unveiling leaching–oxidizing–landing paths of Pd single-atom catalyzed Suzuki–Miyaura reaction by ambient mass spectrometry #ChemSci pubs.rsc.org/en/content/a...

Mechanisms of ionization and of chemical reactions in charged microdroplets Over the past decade the use of electrospray ionization mass spectrometry (ESI-MS) has been extended from the domain of chemical analysis to that of chemical synthesis. This development was spurred by...

Mechanisms of ionization and of chemical reactions in charged microdroplets #ChemSci #MassSpec pubs.rsc.org/en/content/a...

Framework for de novo sequencing of peptide mixtures via network analysis and two-dimensional tandem mass spectrometry Two-dimensional tandem mass spectrometry (2D MS/MS) provides in-depth biopolymer structural information previously not directly accessible with traditional one-dimensional MS/MS workflows, and in sign...

Framework for de novo sequencing of peptide mixtures via network analysis and two-dimensional tandem mass spectrometry #ChemSci pubs.rsc.org/en/content/a...

Spontaneous chiral symmetry breaking in a single crystal Chiral symmetry breaking (CSB) under nonequilibrium open conditions is a ubiquitous phenomenon in the universe, whereas molecular-level CSB is limited. Only the preferential enrichment and Viedma ripe...

A paper by Prof. Ryusei Oketani (桶谷 龍成) et al. has been published in Chemical Science🎉
pubs.rsc.org/en/content/a...

#ChemSci

Graphical abstract for “Breaking the heavy-atom paradigm: weak-donor-engineered triplet harvesting in BODIPY photosensitizers for immunogenic pyroptosis therapy” by Yunjie Xu, Mingle Li, Xiaogang Liu, Jong Seung Kim, et al.

🔥 HOT in Chemical Science!

“Breaking the heavy-atom paradigm: weak-donor-engineered triplet harvesting in BODIPY photosensitizers for immunogenic pyroptosis therapy” by Yunjie Xu, Mingle Li, Xiaogang Liu, Jong Seung Kim, et al.

Read it for free: doi.org/10.1039/D5SC...

#ChemSky #ChemSci

“Copper-catalyzed direct regioselective C5–H alkylation reactions of functionalized indoles with α-diazomalonates” by Shingo Harada, Tetsuhiro Nemoto, et al. from Chiba University, Japan.

🔥 New and HOT in Chemical Science!

“Copper-catalyzed direct regioselective C5–H alkylation reactions of functionalized indoles with α-diazomalonates” by Shingo Harada, Tetsuhiro Nemoto, et al. from Chiba University, Japan.

Read it for free: doi.org/10.1039/D5SC...

#ChemSci #ChemSky

Graphical abstract for “Direct determination of multiphoton absorption cross-sections by transient absorption spectroscopy” by Tze Chien Sum et al. from Nanyang Technological University.

🔥 New and HOT in Chemical Science!

“Direct determination of multiphoton absorption cross-sections by transient absorption spectroscopy” by Tze Chien Sum et al. from Nanyang Technological University.

Read it for free: doi.org/10.1039/D5SC...

#ChemSci #ChemSky

Graphical abstract for “Organic probes for NO-activatable biomedical imaging: NIR fluorescence, self-luminescence, and photoacoustic imaging” by Qingqing Miao (University of Science and Technology of China), Qing Li (Anhui Agricultural University), et al.

🔥 New and HOT in Chemical Science!

“Organic probes for NO-activatable biomedical imaging: NIR fluorescence, self-luminescence, and photoacoustic imaging” by Qingqing Miao, Qing Li, et al.

Read it for free: doi.org/10.1039/D5SC...

#ChemSci #ChemSky

Graphical abstract for “Organic probes for NO-activatable biomedical imaging: NIR fluorescence, self-luminescence, and photoacoustic imaging” by Qingqing Miao (University of Science and Technology of China), Qing Li (Anhui Agricultural University), et al.

🔥 New and HOT in Chemical Science!

“Organic probes for NO-activatable biomedical imaging: NIR fluorescence, self-luminescence, and photoacoustic imaging” by Qingqing Miao, Qing Li, et al.

Read it for free: doi.org/10.1039/D5SC...

#ChemSci #ChemSky

Congratulations to #ChemSci poster prize winner Jacob Simms and to all other prize winners!

Beyond absorption: online photoreactor mass spectrometry assessment of new acylphosphine oxide photoinitiators Tools for the rapid and comprehensive characterisation of photoinitiated polymerisation are required to expedite the development of next-generation photoinitiators. For many current workflows, the tim...

Beyond absorption: online photoreactor mass spectrometry assessment of new acylphosphine oxide photoinitiators #ChemSci pubs.rsc.org/en/content/a...

Large scale relative protein ligand binding affinities using non-equilibrium alchemy Ligand binding affinity calculations based on molecular dynamics (MD) simulations and non-physical (alchemical) thermodynamic cycles have shown great promise for structure-based drug design. However, ...

... or check out the study by Gapsys et al. presented in #ChemSci @rsc.org 🔗 pubs.rsc.org/en/content/a... #alchemy #pmx #MD @gromacs.bsky.social

Synthesis of a Keggin-type polyoxoselenidotungstate via site-selective oxygen-to-selenium substitution Selenium, a group 16 (chalcogen) element, can endow metal oxides with unique properties when replacing oxygen atoms from specific sites. Polyoxometalates (POMs), a class of anionic metal oxide cluster...

Our latest collaboration is now published in @chemicalscience.rsc.org featuring the first-ever fully terminal oxo-to-selenido substitution in a Keggin-type polyoxometalate!🎉
Check out the paper for all the details!
🔗
pubs.rsc.org/en/content/a...
#ChemSci #Polyoxometalates #POMspapers #POMs

Stretchable electrode enabled electrochemical mass spectrometry for in situ and complementary analysis of cellular mechanotransduction Mechanotransduction exerts a profound influence on diverse cellular processes via activated signalling pathways. Although the currently established methods could reveal force-induced ultimate changes ...

Stretchable electrode enabled electrochemical mass spectrometry for in situ and complementary analysis of cellular mechanotransduction #ChemSci pubs.rsc.org/en/content/a...

Original post on fediscience.org

I am going to be at WATOC in Oslo this coming Monday through to Wednesday and would love to chat with any attendees about experiences publishing (be that in Chemical Science, RSC journals, or otherwise!).

Feel free to send me a message here or come by the RSC booth!

And if anyone is looking […]

Cross-disciplinary perspectives on the potential for artificial intelligence across chemistry From accelerating simulations and exploring chemical space, to experimental planning and integrating automation within experimental labs, artificial intelligence (AI) is changing the landscape of chem...

📢 Recently published in Chemical Society Reviews (RSC)

AIchemy Co-Director Kim Jelfs @jelfschem.bsky.social and Imperial Co-Investigators share cross-disciplinary perspectives on AI’s role in chemistry.
🧪 🤖 💻

Read here ➡️ : buff.ly/Ni67NZJ

#AIforChemistry #ChemSci #AIchemy #AcademicPublishing

Mechanically induced polyamorphism in a one-dimensional coordination polymer We created different amorphous structures of a coordination polymer by applying mechanical shear forces. One-dimensional Cu(Tf2N)2(bip)2 (1, Tf2N− = bis(trifluoromethanesulfonyl)imide, bip = 1,3-bis(1-imidazolyl)propane) melted at 245 °C and underwent a glass transition at −10 °C by a static cooling process.

In their latest #ChemSci publication Satoshi Horike and co-workers demonstrate how different amorphous structures of a coordination polymer can be created through the application of mechanical oscillatory shear forces.

Find out more at: doi.org/10.1039/D4SC...
#ChemSky

Rhenium coordination-induced conformational modulation in nitrogen-doped nanographene The conformation of nanographene plays a pivotal role in determining its electronic, mechanical, and optical properties. Analyzing the conformation of nanographene is crucial because of its significan...

💥RSC CNN Paper of the Week💥

Rhenium coordination-induced conformational
modulation in nitrogen-doped nanographene

Chen* (Kaohsiung Medical University, Taiwan)

Varghese, Chemical Science, 10.1039/d5sc02827b
@chemicalscience.rsc.org

#chemsky #nanosky #ChemSci

Enhancing FAIRdata by providing digital workflows from data generation to the publication of data: an open source approach described for cyclic voltammetry Analytical data in chemistry and other disciplines is usually generated in different formats and lacks common data and metadata standards that are necessary for a FAIR handling of research data. In th...

Check out the original #ChemSci publication here:
pubs.rsc.org/en/content/a...

#ChemSky

A bioimmune mechanism-inspired targeted elimination mechanism on the anode interface for zinc–iodine batteries Alkaline byproducts at the zinc anode interface continue to exacerbate subsequent side reactions, so realizing timely salvage of electrodes is equally important compared to upfront prevention strategies. Although the utilization of acid electrolytes could eliminate by-products on the Zn anode, they inevitably exace

Have you seen this new HOT Chemical Science article "A bioimmune mechanism-inspired targeted elimination mechanism on the anode interface for zinc–iodine batteries" by Meng Li et al.?

Read it now for free: doi.org/10.1039/D5SC...

#ChemSci #ChemSky

PCET-mediated deconstructive cross-coupling of aliphatic alcohols A practical deconstructive arylation of aliphatic alcohols has been developed using a synergistic photoredox proton-coupled electron transfer (PCET) and nickel dual catalytic system. The method efficiently generates alkyl radicals via concerted PCET-mediated β-scission, enabling the formation of C(sp3)–C(sp2) bonds

Don't miss the HOT Chemical Science article "PCET-mediated deconstructive cross-coupling of aliphatic alcohols" by Leif Hammarström, Carl-Johan Wallentin, et al.!

Read it for free here: doi.org/10.1039/D5SC...

#ChemSky #ChemSci