Introducing a new addition to our PSAM/PSEM range! 🙌

PSEM89S is a new brain penetrant PSAM agonist which binds to a pharmacologically selective actuator module of genetically engineered chimeric ion channels. 🔬

Take a look at this great new product: ow.ly/VpM550Yhw95

#chemogenetics #ionchannels

Experimental Tips | Understand Chemogenetics in 3 Minutes, Precisely Control Neuron chemogenetics, NELC neurons, rMR pathway, liver regeneration, Th-Cre mice, AAV vectors, CNO administration, neural regulation, chronic stress, liver recovery, proliferation markers, Ki67, PCNA, liver ...

✨ Experimental Tips | Understand Chemogenetics in 3 Minutes, Precisely Control Neuron "Switches" 📣

🔗 Learn more about Chemogenetics & DREADD Technology today!
www.ebraincase.com/support/lite...

#Neuroscience #DREADD #Chemogenetics #NeuralControl #BrainResearch

We know lab budgets are tight - that's why we want to support your research by offering a selection of our products completely FREE via our Free Trial Program 🙌

We've just added chemogenetics ligands to our list of samples - take a look: ow.ly/xcWl50YbBHO

#chemogenetics #DREADDs #DREADDligands

Your Top Technical Questions Answered - How to Solubilise CNO Need help solubilising your CNO? Our technical team answers your latest technical question and demonstrates how to solubilise Clozapine-N-oxide (CNO) dihydrochloride correctly.

🗣️ Your Top Technical Questions Answered!

In this new blog, our technical team share a step-by-step guide to effective solubilisation of CNO 👩‍🔬👨‍🔬

Find out more about one of our most popular DREADD ligands: ow.ly/7ttQ50XhIFA

#CNO #clozapinenoxide #chemogenetics #DREADD #ligands #lifescience #labhacks

Need help solubilising your CNO? 🤔

In this new video we share our recommended method for effective solubilisation using water as a solvent. 🙌

#CNO #clozapinenoxide #DREADD #agonists #chemogenetics #howto #labhacks

www.youtube.com/shorts/lafPb...

Ask the Author: Professor Bryan Roth on the creation of HCAD In our new Ask the Author feature, we speak to Professor Bryan Roth about his team’s new HCAD chemogenetic system. Bryan tells us what makes HCAD different, and why they chose to use Hello Bio’s exclu...

In our new Ask the Author feature, we speak to Professor Bryan Roth about his team’s new HCAD chemogenetic system. 👨‍🔬

@zenbrainest.bsky.social tells us what makes HCAD different, and why Hello Bio's FCH-2296413 proved such a valuable research tool: ow.ly/70HN50W7Mga

#chemogenetics #lifescience

Parvalbumin-expressing neurons in the ventral medulla are active during wakefulness and promote NREM sleep Abstract. A longstanding hypothesis contends that sleep is promoted by sleep-active inhibitory neurons that suppress arousal centers. Sleep may also be fac

This study, out in #SLEEP, used #chemogenetics, fiber photometry and circuit mapping to identify subset(s) of inhibitory neurons promote NREM sleep.
academic.oup.com/sleep/articl...

The interpeduncular nucleus blunts the rewarding effect of nicotine Nicotine activates the dopamine reward system to promote consumption and addiction, but the brain has a natural brake to counteract it. Jehl, Ciscato, Vicq, Guyon, et al. identified the interpeduncula...

Super happy to see our new study, on how the interpeduncular nucleus (IPN) regulates nicotine reward, out today in @cp-neuron.bsky.social!

Using #chemogenetics, we @faurelab.bsky.social show that blocking IPN activation enhances VTA responses and increases nicotine's rewarding effect.
#neuroscience

Original post on rna-mediated.com

Meta AI vs xAI (3) A sensitive miRNA detection method based on a split-T7 switch modulating CRISP...

rna-mediated.com/2025/02/26/meta-ai-vs-xa...

#Adaptations #base #editing #biophotonics #Chemogenetics #amino #acid […]

Original post on rna-mediated.com

Antagonistic AI vs common sense (9) See first: Antagonistic AI vs common sense (8) “Let’s fol...

rna-mediated.com/2025/02/16/antagonistic-...

#Adaptations #Autophagy #biophotonics […]

Video 3(of 3) in our series on changing brain activity in animal models: #Chemogenetics.

This video by Corina Damian & Juan Song explains how small molecules coupled with genetically modified receptors can activate or inhibit neurons and thereby teach us about the brain!

youtu.be/LOIlPlfB8u8

The surprising effect of stress on your brain’s reward system Some people bounce back from trauma, but others get caught in depressive loops that sap the joy from their lives.

"She used a technique called chemogenetics, which employs artificial molecules that interact inside the body.

The team attached one of the molecules, a receptor, to the surface of neurons in the hippocampus to make them fire."

Science is crazy!
#UCSF #chemogenetics

Our paper on dmPAG Tac2 neuron in aggression is out. From Fos mapping, Ca2+ imaging, #chemogenetics to viral TRAP profiling, then validation. I think this is a great way to link a neuron type to a function. thno.org/v15p0707.htm #Theranostics love every minute of it, my first co-correspondent paper💪

With a catalog of nearly 100K (!) items available, @Addgene would not be a useful resource if our scientists did not put a lot of effort into curating our enormous, diverse collection. For example, take a look at our newly updated #Chemogenetics Guide:...

Today during lunch @Addgene , @leilahaery is teaching us about #chemogenetics ! I think this pic conveys her enthusiasm for the topic well!