DNA damage caused by #ChromosomalInstability boosts #cancer cell invasiveness. #Caspase activation plays a key role in this process.

Image by Mariana Muzzopappa, from @milanlab.bsky.social.

📌 https://doi.org/10.1016/j.cub.2023.09.004

🧪🐡

🚨 New Commentary now online!

💭 CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability

👉 buff.ly/XbmDlvT

🖊️ @eileenparkes.bsky.social

#RNAsensing #ChromosomalInstability

Job Vacancy at the University of Surrey: Research Fellow in Cancer Evolution The University of Surrey is a global community of ideas and people, dedicated to life-changing education and research. We are ambitious and have a bold vision of what we want to achieve - shaping ours...

Are you interested in cancer genomics and cancer evolution? A 3-year postdoc position available
to join my MRC-funded project on #ChromosomalInstability #CancerPhylogenetics!
Please get in contact if you are interested.
Deadline 30 Apr 2025.
jobs.surrey.ac.uk/017125

#PoloLikeKinase1 overexpression🐭->
#ChromosomalInstability #Aneuploidy #Ployploidy #Senescence in #BreastCancer
⏫SASP (IL1RN/IL6/CXCL1)
⏫PD-L1
Reshaped immune niche:
⏫Treg⏫Dendritic cell⏫Arg1+TAM⏬NK

PLK1-hi👤breast tumors->⏫Immunopressive features

#CellRep 2023
www.sciencedirect.com/science/arti...