A circle plot combines obtained N-termini from the cross-sectional SLE cohort (in vivo), longitudinal perspective in remission (in vivo) and the recombinant complement protease assays (in vitro) - all pointing towards C3-LHF1 cleavage as a central element.

Combining all of this data into a fabulous circle plot clearly pointed towards an important role of the cleavage at pos. 1514, generating C3-LHF1. This became the focus of our future efforts. #LHF1 #CirclePlot