A circle plot combines obtained N-termini from the cross-sectional SLE cohort (in vivo), longitudinal perspective in remission (in vivo) and the recombinant complement protease assays (in vitro) - all pointing towards C3-LHF1 cleavage as a central element.

Combining all of this data into a fabulous circle plot clearly pointed towards an important role of the cleavage at pos. 1514, generating C3-LHF1. This became the focus of our future efforts. #LHF1 #CirclePlot

Investigation of the human plasma N-termini identifies the cleavage of the human complement C3 protein at position 1514 leads to generation of C3-LHF1. This C3-LHF1 significantly inhibits the classical and MBL pathways of the human complement system and interacts with the IL6ST/gp130 receptor, leading to IL6 signalling as evident from reporter cell line assays and (phospho-)proteomics screens.

After a looong journey, here the results of a deep investigation of human plasma proteolysis by MS: SLE N-terminomics paper with a complement C3 fragment at the core, EMBOJ: www.embopress.org/doi/full/10.... - highlights: a resource on proteolytically processed N-termini in human plasma #LHF1 #SLE🧪

After brain transplant, Ferrari is expected to announce Roscoe Hamilton as its new driver alongside Charles Leclerc. #ScuderiaFerrari #roscoelovescoco #SaveRoscoe #RoscoeHamilton #TeamLH #LH44 #44 #LHF1 #LewisHamilton #F1 #FIA

"I’m hungry, driven, don’t have a wife and kids. I’m focused on one thing, and that’s winning. That’s my No. 1 priority.” (Lewis Hamilton) #NicoleScherzy #roscoelovescoco #SaveRoscoe #TeamLH #LH44 #44 #LHF1 #LewisHamilton #F1

ℹ️ tinyurl.com/nhax33h3

Roscoe dreams of being an F1 driver... #roscoelovescoco #SaveRoscoe #TeamLH #LH44 #44 #LHF1 #LewisHamilton #F1

Lewis Hamilton said that he doesn't feel any more comfortable in his Ferrari. When asked what he needs to get to grips with the SF-25 he replied: “A brain transplant.” (RaceFans) #roscoelovescoco #SaveRoscoe #TeamLH #LH44 #44 #LHF1 #LewisHamilton #F1