#ClickBaitKiller "... persistent elevations of proinflammatory mediators such as TNF, CCL2 and CXCL11 up to 9 months after infection.... a distinct circulating CD14⁺ monocyte state (LC-Mo) associated with LC... showed increased TGFβ/WNT–β-catenin signaling that increased over time."

"the surgery described in the Post is exactly the procedure known as top surgery, which transgender men and some nonbinary people seek for similar reasons"

#ClickBaitKiller

#ClickBaitKiller hifiasm, Haoyu Cheng, Heng Li, co-authored with ONT staff.

"Compared to HiFi-based assembly graphs, ONT-based assembly graphs tend to be more accurate, cleaner, and resolve more repetitive regions. This... substantially improves existing methods in [the] hifiasm toolkit"

#ClickBaitKiller #COVID19

"There was an enrichment of genes with altered methylation at transcription start sites associated with inflammation and the immune system in the COVID-19 data set, which might reflect an attempt to dampen inflammation and immune responses."

#ClickBaitKiller Alpha-synuclein oligomers

Header text from a Stuff article dated September 9, 2025: "Labour and Stuff Find More Reasons to Encourage Harassment of Te Pāti Māori" [original text was: "Govern with Te Pati Māori? The dilemma Labour’s grappling with"]

#ClickBaitKiller #RewritingBadHeadlines

Header text from a Stuff article dated September 9, 2025: "Lorde says her pronouns haven't changed, talks about clinical depression, and that she doesn't like Lord Of The Rings" [original text was: "Lorde opens up about gender, drug use, and why she thinks she's a 'bad Kiwi'"]

#ClickBaitKiller #RewritingBadHeadlines

#ClickBaitKiller The Medical Evidence Project will identify scientific integrity concerns that are leading to actual / immediate medical threats, and report on those issues as quickly as is responsibly possible.

If the concern is serious enough, people will be paid for peer review of findings.

#ClickBaitKiller metformin relieved osteoarthritis pain

#ClickBaitKiller The question isn't answered explicitly.

R and Python appear to be mentioned in equal proportions.

I personally think researchers should start with R because it gets you quickly to plotted data, and through Bioconductor has good dependency QC and a great library / tool diversity.

(a) WEHI-P8 was selected for mouse in vivo efficacy due to its favourable ADME properties. (b) Calculated unbound plasma concentration of WEHI-P8 in male C57BL/6 (WT) mice following oral administration at 100 mg/kg [decreases over time from about 0.5 to 0.1]. (c) Schematic showing treatment regime used in d-g. Mice were treated at 6 h, 24 h and 48 h with euthanasia performed at 72 h post-infection. WT 7-9 week-old mice were infected with SARS-CoV-2 P21 and treated with either vehicle, PLT (Paxlovid-like treatment: 56 mg/kg nirmatrelvir, 19 mg/kg ritonavir), or WEHI-P8 (100 mg/kg or 150 mg/kg) (d,e) At 3 days port-infection (dpi), mice were monitored for (d) viral burden [decreased from vehicle with PLT, decreased further with WEHI-P8 at 100 mg/kg, decreased further with WEHI-P8 at 150 mg/kg] and (e) percent weight change compared to initial weight; nvehicle = 7, nPLT = 7, nP8-100 = 8, nP8-150 = 8 mice per group. Mean ± SD [weight change for all conditions except WEHI-P8 at 100 mg/kg is negative].

#ClickBaitKiller WEHI-P / PLpro inhibitors that target coronaviruses through a binding mode distinct from known scaffolds and show potential as pan-coronavirus antivirals.

WEHI-P8 is effective at reducing SARS-CoV-2 levels #InMice.

doi.org/10.1038/s414...

#ClickBaitKiller

"... paying for reviews moderately improved both the number of accepted invitations and the speed at which reviews were carried out."

"Editors found no difference between the quality of paid and unpaid reports."

There's also speculation about what might happen, but doesn't.

#ClickBaitKiller The "see more" link is an email address collecting page [that claims to provide even more details via email].

The form will be closed after orders for 100 samples have been filled. Orderers will be given the raw reads, assembled genome and access to the Solu Platform results.

How short inserts affect sequencing performance | Illumina Knowledge

This reads like it was written by an LLM.

In any case...

For Illumina systems the optimal DNA insert size is 450bp, with an acceptable range of 200–800 bp

I have a suspicion that chimeric reads ["barcode swapping"] are increased as insert size increases.

#ClickBaitKiller

#ClickBaitKiller Immune escape: [omicron's] ability to evade SARS-CoV-2 immunity caused by either vaccination or past infection

In other words, think about what worked *before* vaccines were an option, and do that.

#Level4