New protocol 🚨
Co-culture RealDRG™ sensory neurons with RealDHN™ dorsal horn neurons on the eNUVIO OMEGA4 to model functional pain circuits and sensory–spinal connectivity.
Flexible workflow: use RealDRG™ alone or swap in your cell type of choice.
#CompleteTheCircuit #NotYourAverageNeuron
🎥 A glimpse into our 7-day directed differentiation of human iPSC-derived dorsal horn neurons. Fast. Reproducible. Ready for pain pathway discovery.
#NotYourAverageNeuron #CompleteTheCircuit #neuroscience #drugdiscovery #iPSC #dorsalhorn #painresearch
Motor neurons alone can't explain ALS or CMT. Schwann Cell Precursors reveal how disrupted glial-neuronal crosstalk drives disease. Co-cultures model early pathogenesis, glial dysfunction, and myelination defects more accurately.
#CompleteTheCircuit #NotYourAverageNeuron
Add These Publications to Your Reading List 📚
Explore all publications featuring Anatomic’s products in one place — a fast way to find relevant assays and new applications.
See how our models are advancing discovery: www.anatomic.com/publications
#CompleteTheCircuit #NotYourAverageNeuron
Exciting synaptic insights! 🟢
Using Anatomic’s nociceptors & dorsal horn neurons, VGLUT2 (green) shows glutamate at synapses, while TUJ1 (red) highlights neurons.
#CompleteTheCircuit #SensoryNeurons #PainResearch #DorsalHornNeurons #NotYourAverageNeuron
💡 Integrating Schwann cell precursors (SCPs) into motor neuron (MN) cultures enhances relevance by replicating human physiology. As SCPs mature, they migrate and align along axons, visualized via S100b/SOX10 (SCPs) and TUJ1 (MNs) staining.
#CompleteTheCircuit #NotYourAverageNeuron #ALSResearch
Anatomic has been focused on developing CIPN-related assays for the last few years. The FDA’s new draft guidance underscores the need for better study designs and endpoints in CIPN research.
Read the full guidance below!
#CompleteTheCircuit #CIPNResearch
💎Check-out the purity💎 Images of co-cultures of RealSCP, hiPSC-derived Schwann cell precursors, and RealDRG, hiPSC-derived sensory neurons, generated without the need for genetic engineering or Mitomycin C.
#CompleteTheCircuit #NotYourAverageNeuron
It’s always tough to pick favorites when there’s so much exciting data to explore! 🤩 We have compiled our favorite data from over the years onto a new page for your easy access.
Check out our data highlights page at www.anatomic.com/datahighlights
#CompleteTheCircuit #NotYourAverageNeuron
🧒🏻👧🏽👦🏼👩🏽🦱Multiple donors. Same process. Sensory neurons derived from hiPSC lines (both healthy and diseased) express key ion channel targets for pain - NaV1.7, NaV1.8, and TRPV1.
#NotYourAverageNeuron #CompleteTheCircuit #DiseaseModeling #PainResearch
💡 Paclitaxel, first FDA-approved in 1992 for ovarian cancer, is linked to chemotherapy-induced peripheral neuropathy (CIPN). Imaging shows dose-dependent cytotoxicity in sensory neurons & Schwann cell precursors, with co-cultures altering responses.
#CompleteTheCircuit #CIPN #PainResearch
🔎How do you “spot” a melanocyte? You look with your naked eye!
With RealMELO, Anatomic is going MACROSCOPIC! If your drug screen readout is pigmentation, the effects will be obvious in as little as 7 days post-thaw!
#CompleteTheCircuit #Vitiligo #Melanoma #Cosmetics
Sensory neurons and Schwann cells are better together❣️
Whether you are single or have date night plans, this is a scientific love story that you can study this Valentine’s day.
#CompleteTheCircuit #NotYourAverageNeuron #PainResearch #CoCultures #CMT
Motor neurons 🤝 Schwann cell precursors
Adding SCPs enhances ALS models by increasing physiological relevance. As co-cultures mature, SCPs align with axons—the first step of myelination!
Learn more: support@anatomic.com
#CompleteTheCircuit #NotYourAverageNeuron
#SLAS2025 ✅ Kicking off the year with exciting progress!
We shared our latest work on Schwann cell integration into our CIPN sensory neuron model, along with advancements in other cell types. Great discussions, collaborations, and insights—let’s keep the momentum going!
#CompleteTheCircuit
🔗 Decoding Motor-Schwann Interactions! 🔬
ICC reveals neuron morphology & Schwann cell distribution, while qPCR tracks myelination markers over time.
Schedule a call to learn more!
#CompleteTheCircuit #PainResearch #NotYourAverageNeuron
#CompleteTheCircuit with Dorsal Horn Neurons
Dorsal horn neurons link DRG cells to the CNS, key for processing touch, pain, and temperature. Disruptions can lead to chronic pain.
Discover our iPSC-based models driving pain research!
#stemcells #neuroscience
Did you know Schwann cells are the most abundant glial cells in the peripheral nervous system? 💡
In these images, hiPSC-derived Schwann cell precursors (S100b, SOX10) align increasingly with hiPSC-derived motor neurons (TUJ1) over time in culture.
#ALS #CompleteTheCircuit #NotYourAverageNeuron
