Thanks to many co-authors from our group, including #ZoranGajic (former MD-PhD & computational genomics star), #ChristinaCaragine, #XiaoWang, @rachelyan.bsky.social , #HarmWessels & #CongyiLu.

A special shout-out to #MatLegut, #JamesKim & #NeilBapodra who launched this project many years ago! 🙏

Essential transcription factors for induced neuron differentiation - Nature Communications Using integrative multi-omics and CRISPR knock-out of all ~1,900 transcription factors, the authors identify essential transcription factors required for Neurogenin-driven differentiation of human cor...

For this, we took advantage of recent work from former lab member #CongyiLu (collab w/ #EstebanMazzoni lab). 🔥

She used a TFome-wide CRISPR KO library that targets all ~2,000 human TFs (10 gRNAs per TF) to find essential TFs to make neurons: ✂️⚙️🧠
www.nature.com/articles/s41...