📝 Online now - the Review "Diversity in CDK structural mechanisms of regulation and drug discovery opportunities" from Rhianna Rowland, Martin Noble, and Jane Endicott.

#CDK #Cyclins #ShortLinearMotif #StructureBasedDrugDesign

Read it here: authors.elsevier.com/sd/article/S...

Plasticity of mitotic #cyclins in promoting the G2–M transition. A new study from Adrijana Crncec, Ho Wai Lau, Lau Yan Ng, Randy Yat Choi Poon and colleagues.

#Mitosis #CellCycle #CellDivision

Crncec et al reveal that individual mitotic cyclins’ roles are more flexible than previously thought. Deficiency of B-type #cyclins inhibits mitotic entry, leading to mitotic slippage. But elevating cyclin A levels can restore #mitosis independently of B-type cyclins rupress.org/jcb/article/...