A framework for prospective, adaptive meta-analysis (FAME) of aggregate data from randomised trials Jayne Tierney and coauthors discuss FAME, an approach for adaptive meta-analysis of data from randomised trials.

#DADSPORT shows how collaboration can push aggregate data towards #IPD quality, but much quicker. Our #MetaAnalysis framework #JustFAMEIt has shown similar advantages in other projects, particularly if review can be designed & planned before trial results are known.
doi.org/10.1371/jour...

Duration of Androgen Suppression with Postoperative Radiotherapy (DADSPORT) for Nonmetastatic Prostate Cancer: A Collaborative Systematic Review and Meta-analysis of Aggregate Data - Beyond the Abstra... Prostate Cancer, Nonmetastatic Prostate Cancer, DADSPORT trial, RADICALS-HD, NRG/RTOG 9601, Androgen Suppression, Androgen Suppression with Postoperative Radiotherapy for Nonmetastatic Prostate Cancer...

#DADSPORT results were based on ≥95% of eligible pts. Pre-agreed subgroup analyses were far more complete than if using published results alone. We also requested additional data to overcome trial nuances. Remember, this was not an #IPD review!
www.urotoday.com/recent-abstr...

Key strength of #DADSPORT was close collaboration with trial investigators, giving crucial insights, complete data & better interpretation. Most reviews rely on information from trial publications, risking reporting bias. By contrast, our protocol set out specific data items to be requested.

DADSPORT meta-analysis results show hormone therapy can delay prostate cancer spread | MRC Clinical Trials Unit at UCL

Do #ProstateCancer patients benefit from hormone therapy (HT) added to radiotherapy (RT) after surgery? To find out, the #DADSPORT collaborative #SystematicReview & #MetaAnalysis collected aggregate data from 5 eligible trials (4411 pts). @euplatinum.bsky.social
www.mrcctu.ucl.ac.uk/news/news-st...