🧠 New preprint by Ruff et al. (2025): #NeuralPopulation formatting matters for function. In monkeys, #MT encodes motion & reward separately, #dlPFC integrates them. An #RNN predicted, and microstimulation confirmed, distinct #behavioral impacts.
#Neuroscience 🧪 #CompNeuro 💻#DecisionMaking
Aujourd'hui dans Stimuli!
La recherche fondamentale propose de nouvelles pistes pour soigner la dépression résistante, notamment en ciblant les réseaux préfrontaux responsables de l'anxiété et de la motivation !
#Neuroscience #Dépression #Anxiété #DLPFC #Cerveau
stimuli.blog/2025/09/04/d...
The resulting cell type proportions had a large range across the different #DLPFC samples, and were not always correlated with the paired #snRNAseq proportions ⚠️
We designed an #RNAScope/IF experiment to measure six broad cell types in the #DLPFC. We used #HALO from Indica Labs to count the occurrence of the cell types across the tissue sections 🔬 #ImmunoFlourescence (awesome work from Kelsey Montgomery)
Testing these #deconvolution methods was made possible by a really cool multi-assay dataset from consecutive slices of #DLPFC tissue blocks 🧠1. Bulk RNA-seq 🧬 2. #snRNAseq as the reference 🦠 3. #RNAScope serving as a orthogonal measurement of cell type proportions 🔬
Hey #deconvolution fans! 👀 We’ve got an exciting new publication for you: a benchmark of 6 popular deconvolution methods on a multimodal human brain #DLPFC dataset 🧠🧬
Now out in Genome Biology: doi.org/10.1186/s130...
@lieberinstitute.bsky.social @jhubiostat.bsky.social
Brain stimulation can change how much we enjoy and value music www.mcgill.ca/neuro/channels/news/now-... #TMS #DLPFC
