DMTF1 up-regulation rescues proliferation defect of telomere dysfunctional neural stem cells via the SWI/SNF-E2F axis DMTF1 up-regulation promotes proliferation of “aged” neural stem cells by regulating the SWI/SNF-E2F axis.

𝗦𝗰𝗶𝗲𝗻𝘁𝗶𝘀𝘁𝘀 𝗱𝗶𝘀𝗰𝗼𝘃𝗲𝗿 𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝘁𝗵𝗮𝘁 𝗿𝗲𝗷𝘂𝘃𝗲𝗻𝗮𝘁𝗲𝘀 𝗮𝗴𝗶𝗻𝗴 𝗯𝗿𝗮𝗶𝗻 𝗰𝗲𝗹𝗹𝘀 [via Science.org] 🧪🥼🧓🧠🩺🧒

"DMTF1 is down-regulated in telomere dysfunctional NSCs and that its up-regulation rescues the defect"

www.science.org/doi/10.1126/...

#telomere #erosion #synaptic #plasticity #aging #brain #health #DMTF1