The 2025 DPUK Annual Report shows major progress across dementia research. As the DPUK Data Portal, we’re proud to help power it, from harmonised datasets to secure TREs, hubs and federation tools. When infrastructure and innovation meet, research moves faster. #DPUK #DataPortal #TRE #MRC #Dementia

📚 340+ publications enabled or cited DPUK in the last 5 years
Our reach is broad. Our impact is real.
From data infrastructure to research collaborations - we're supporting discoveries that matter.
#DementiaResearch #ResearchImpact #DPUK

🤖 NEW REPORT: AI in Sensitive Healthcare Data
Our data team @SwanseaUni with @DAREuk produced this vital report on unique challenges of complex multi-modal data in health research.
Download: zurl.co/qTFI0
#AI #HealthData #DPUK

🧠 300,000+ neuroimaging scans on our Data Portal
Pre-loaded analysis tools. Growing all the time.
Researchers: Check our Imaging Matrix to see what's available 👇
zurl.co/Ww377
#Neuroimaging #DementiaResearch #DPUK

🎯 72,000 people in our Trials Delivery Framework registers
Trial & study researchers can access Great Minds and CSR - pre-clinical dementia registers totalling 72,000 people.
Accelerating recruitment = accelerating discoveries.
#ClinicalTrials #DementiaResearch #DPUK

🎉 500 participants recruited to READ-OUT in its first year!
#DPUK blood biomarker study launched in January and already hit this incredible milestone.
Our volunteers are helping identify blood tests for dementia to roll out across the NHS. #DementiaResearch #Biomarkers

🚀 2,000 recruits to our FAST study!
Assessing feasibility & accessibility of blood tests for dementia through data & samples from people over 50 - cognitively healthy or with MCI.
Building the evidence base for next-gen diagnostics.
#DementiaResearch #ClinicalTrials #DPUK

🌍 Find dementia data sources globally
Our searchable Data Landscape Report covers:
📊 Clinical Trials
🧠 Dementia Datasets
👥 Research Registers Worldwide.
Explore: zurl.co/2MWPR
#OpenData #DementiaResearch #DPUK

Welcome

🧠 13,500+ people on our Great Minds Register!
Highly characterised volunteers ready to join health studies and accelerate dementia research.
Want to make a difference? Join Great Minds 👇
zurl.co/4grwF
#DementiaResearch #GreatMinds #DPUK

📈 Delivering for dementia research!
15% increase in study applications for our Data Portal this year. More researchers = more discoveries.
(Except when COVID struck - we don't talk about that year 😉)
#DementiaResearch #OpenScience #DPUK

What next for GLP-1 receptor agonists and dementia? Novo Nordisk's EVOKE trial didn't meet its primary endpoint - semaglutide didn't slow cognitive decline in people with early Alzheimer's. But the results revealed something intriguing: reductions in biomarkers of neurodegeneration, inflammation, and tau protein. The drug does something to Alzheimer's biology - the question is when to use it.

What next for GLP-1 receptor agonists and dementia?
So, semaglutide didn't slow cognitive decline in early Alzheimer's, but there were positive outcomes. Read Ivan Koychev's reflections. zurl.co/PaL1s
#DementiaResearch #AlzheimersResearch #ClinicalTrials #Prevention #DPUK #GLP1

#DPUK has groundbreaking #dementia studies in our Experimental Medicine Incubator. We’re running 7 randomised trials and 31 observational studies.

Our work could be key to better treatment in future." – Prof. James Rowe, Cambridge University

Read more zurl.co/iVIQS

Dementia is now the UK's most feared illness, reports @Telegraph. At #DPUK, we understand the urgency. We're accelerating research by connecting scientists with crucial data to develop better treatments. Together, we can change the future. zurl.co/st2Ee #BrainHealth

@dementiaresearcher.bsky.social
📢 Advance Notice – Festive Service
Plan ahead:
✅ Last file-out: 17 Dec (midday)
🔒 No helpdesk/email: 19 Dec – 5 Jan
Portal stays open, but requests after 17 Dec processed after 5 Jan.
Seasons Greetings
#DPUK #ResearchData

We’re at the ARUK Networking Meeting in Cardiff!
🧠 AI-driven neuroimaging talk by @lewishotchkiss.bsky.social
📊 Posters on Polygenic Risk Scores by Alieyeh Sarabandi & Aynthetic Data by Kafayat Adeoye
Come say hi and learn how DPUK drives dementia research!
#DementiaResearch #AIinHealthcare #DPUK

DPUK Platform team is heading to the @alzheimersresearchuk.org Scientific Networking Event on Tues 18 Nov!
🎤 Lewis Hotchkiss talks AI & neuroimaging
📌 Posters by Alieyeh Sarabandi & Kafayat Adeoye

#DementiaResearch #AI #Neuroimaging #DPUK

A collage of four photos from the “Synthetic Data Public Workshop.” Each photo shows a meeting room with participants seated around tables, listening to presenters who are standing near large screens displaying slides. The slides include text and graphics about synthetic data and governance. The room has exposed brick walls and arched ceilings with greenery hanging from beams. Branded banners for the UK Synthetic Data Community Group are visible in the background. The bottom of the image features the UK Synthetic Data Community Group logo and name.

Yesterday, DPUKPortal & UK Synthetic Data Community Group ran a public workshop on making synthetic data from Trusted Research Environments available.
Public input is vital in shaping governance ideas. Thanks to all who joined!
#SyntheticData #PublicTrust #HealthData #DPUK #Innovation #DataEthics

Great Minds event 'Decoding Dementia: Biomarkers, Big Data, and the Future of Diagnosis' is now available to watch 🧠

Featuring #DPUK experts discussing blood-based biomarkers, AI, and NHS readiness

Watch here: www.youtube.com/watch?v=kvQE...

#DementiaResearch #Biomarkers

🧠 GREAT MINDS LIVE - 16 October, 2-5pm
Join leading #DPUK experts exploring blood #biomarkers, #AI, and research registers in #dementia
📅 Thursday 16th October, 2-5pm
📍 Said Business School
💰 FREE
Book:
Venue zurl.co/n7Npj
Online zurl.co/wbTus

Prof Sarah Bauermeister has been speaking at the #TBI-Reporter conference today about curation of data at scale. At #DPUK she developed the #C-Surv #ontology enabling highly effective data management. #braininjury #dataanalysis # dementia #trauma @oxfordpsychiatry.bsky.social

It's great to hear about the huge amount of work going on with traumatic brain injuries at the TBI_REPORTER General Assembly this week. A key resource is its #hub hosted on #DPUK's data portal (@dpukdataportal.bsky.social) - which is collating & curating #braininjury research data at scale. #TBI

Great to have DPUK engaged at #VasCog 2025 yesterday. Notable contributions from #AtticusHainsworth and #JoannaWardlaw. We are looking forward to some really interesting #DPUK #vascular #dementia research in future, building on our existing work. #cognition #brain @ukdri.ac.uk

GREAT MINDS LIVE - Booking to attend 'in person' The future of biomarkers and the importance of registers in dementia research

🧠 GREAT MINDS LIVE - 16 October, 2-5pm: The Future of #DementiaResearch

Join leading #DPUK experts exploring blood #biomarkers, #AI, and research registers in #dementia

📅 Thursday 16th October, 2-5pm
📍 Said Business School
💰 FREE

Please register: zurl.co/n7Npj

With 107 multimodal datasets - accessible in one place - the #DPUK Data Portal is a fundamental tool for dementia research. Data includes lifestyle, cognition tests, brain imaging, and genetics. Check it out. Use our Discovery Tools zurl.co/Klv2R

Alzheimer’s risk may start at the brain’s border, not inside it Your brain has its own elite defense team — and new research shows these "guardian" cells might be the real battleground for neurological diseases like Alzheimer’s and stroke. Scientists discovered that most genetic risks linked to these diseases act not in neurons, but in the blood vessels and immune cells that form the blood-brain barrier.

Your brain's "guardian" cells might hold the key to Alzheimer's risk! 🧠 New study shows genetic factors act at the brain's border, not just neurons. Game-changer for therapies? zurl.co/9PfcS #DPUK #AlzheimersResearch

Vaccines hold tantalizing promise in the fight against dementia A prominent Nature study and related research raise the possibility that vaccines may have a broader role in experimental therapeutics outside the realm of infectious diseases.

💉 Could your routine jab protect your brain? New research shows vaccines for shingles, tetanus & pneumonia may reduce dementia risk. "Trained immunity" could be key to cognitive protection. Read more: zurl.co/jb1BY

#BrainHealth #DementiaPrevention #Innovation #DPUK

Fuel for thought.

🧠 New blog from PhD researcher Megan Smith: How the MIND diet shows cognitive benefits 12+ years later, whilst ultra-processed foods increase dementia risk.
"Food has the potential to either support or hinder our brains"
Read more: zurl.co/3JDkk#DementiaResearch #DPUK

U.S. POINTER | Study Results | Alzheimer's Association Clinical trial results showed that a lifestyle program incorporating physical exercise, diet, cognitive & social engagement, & health monitoring improves cognitive function.

🧠The U.S. POINTER study found that combining exercise, healthy eating & brain training protects thinking and memory. Important findings for dementia research and prevention.
Read full study results here zurl.co/ISBG7 #BrainHealth #DementiaResearch #DPUK #HealthyAging

Worth noting for dementia researchers: Alzheimer's Research UK's Pilot Project Scheme offers up to £70k for exploratory research. #DPUK 's Data Portal can support these pilot studies with data access. Deadline 15 Oct.

#DementiaResearch #ResearchFunding #DPUK

Machine learning in Alzheimer’s disease genetics - Nature Communications Here the authors apply machine learning approaches to Alzheimer’s genetics, confirm known associations and suggest novel risk loci. These methods demonstrate predictive power comparable to traditional approaches, while also offering potential new insights beyond standard genetic analyses.

AI identifies new genetic factors in Alzheimer's research.
Great to see #DPUK colleague Valentina Escott-Price (@cardiffuni) as part of this research with @UniofOxford & KU Leuven teams, using machine learning to uncover 6 new Alzheimer's-linked genes from 250,000 genetic variants zurl.co/T4VbK