The dentate gyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental representations - Nature Neuroscience This study reveals how the dentate gyrus gradually learns to integrate olfactory and spatial signals from the entorhinal cortex, transforming them into sparse and highly specific representations that ...

The #dentategyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental #representations
doi.org/10.1038/s415...

Identification of an engram ensemble mediating memory forgetting in the dentate gyrus Hu et al. show that the dentate gyrus engram comprises two neuronal ensembles: one supports remembering, and the other promotes forgetting. By shifting the balance between these ensembles via Rac1 sig...

Interesting, but I feel like this needs to be replicated.

Identification of an #engram #ensemble mediating #memory #forgetting in the #dentategyrus: Neuron www.cell.com/neuron/fullt...

Adverse gestational environment configures a subpopulation of ventral dentate granule cells for recruitment to drive innate anxiety Nabila et al. show that the transcriptomic impact of gestational adversity is variable across hippocampal neurons and that the most affected neurons are activated during stress. These neurons exhibit ...

🧪🧠🚼Adverse gestational environment configures a subpopulation of ventral dentate granule cells for recruitment to drive innate anxiety www.cell.com/cell-reports... #DentateGyrus

Researchers identify 129 genes enriched in murine NPCs, including 15 genes linked to novel neurological conditions, highlighting NPC molecular mechanisms in brain development and disease. #dentategyrus ow.ly/aIUq50WJMHi

@bcmhouston.bsky.social @isscr.org

7️⃣To sum up, our work shows that Sox5 is crucial to balance shallow and deep #Quiescence in NSCs during the first postnatal weeks of #DentateGyrus development. This balance ⚖️ is crucial for long-lasting #AdultNeurogenesis✨🔬

3️⃣When Sox5 is lost, there is an accumulation of shallow quiescent NSCs at P14 more prone to activation. This causes a neurogenic burst in the adult #DentateGyrus at P30 and ultimately results in a premature depletion of the NSC pool. Essentially, too much too soon leads to not enough later !!

1️⃣Here we show that Sox5 is crucial for developmental NSCs to enter #Quiescence and for long-life maintenance of the adult stem niche in the #DentateGyrus of the #Hippocampus . Do you want to learn more?
journals.plos.org/plosbiology/...
@institutocajal.bsky.social @csic.es @csicdivulga.bsky.social

Proof That Adult Brains Make New Neurons Settles Scientific Controversy Adult brains grow new neurons, and scientists have finally pinpointed where they come from

Adult brains do make new neurons [via @sciam.bsky.social] 🧪⚗️⚕️🧠💭

"if adult neurogenesis happened anywhere, it was in the #hippocampus, a deep-brain structure known for its role in memory processing and storage."

www.scientificamerican.com/article/proo...

#adult #neurogenesis #brain #DentateGyrus

Regionalized loss (CA1/2/3/4 #DentateGyrus) of Hippocampal #Pericytes in👤#Stroke #VascularDementia #AlzheimersDisease

ColIV IHC + Abluminal soma to identify pericytes on 10-μm section

#ActaNeuropatholCommun 2024
actaneurocomms.biomedcentral.com/articles/10....