Human pluripotent stem cell engineering with CRISPR-Cas9 for Parkinson's disease Parkinson’s disease (PD) is one of the most age-dependent prevalent neurodegenerative disorders, affecting approximately 10 million people worldwide and imposing a growing clinical and economic burden as populations age1,2,3. Pathologically, PD is characterized by the progressive degeneration of dopamine (DA)-producing neurons in the substantia nigra pars compacta and the formation of Lewy bodies (LBs), which result from the aggregation of misfolded α-synuclein (α-syn), leading to debilitating motor symptoms. Current standards of care, most prominently DA replacement with levodopa, can provide temporary symptomatic relief. However, they neither halt disease progression nor address the underlying neuronal loss, and their efficacy invariably diminishes over time, whereas adverse effects accumulate2,3,4. Thus, it is essential to develop mechanism-directed strategies that move beyond symptomatic relief, together with precise human models that capture the molecular determinants of DA neuron vulnerability and regenerative approaches that replace or protect degenerating DA neurons. Conventional PD animal models, particularly those related to PD-linked toxin-induced and transgenic rodent models, have been crucial for elucidating the molecular and cellular mechanisms underlying the degeneration of DA neurons. However, these animal models insufficiently recapitulate key human-specific aspects of PD pathophysiology, including the progressive and selective degeneration of midbrain DA neurons and LB-like α-syn pathology. Such...

Human pluripotent stem cell engineering with CRISPR-Cas9 for Parkinson's disease
->Nature | More on "CRISPR stem cell Parkinson's treatment" at BigEarthData.ai | #Disease #Health

More steps cut chronic disease risk but cannot fully undo long sitting Tracking over 13 million days of real-world activity, researchers reveal how step counts can counter some harms of prolonged sitting, while warning that too much sedentary time still carries lasting risks for the heart. Study: Daily steps offset risks of sedentary behavior in the All of Us research program. Image credit: Jacek Chabraszewski/Shutterstock.com Over one in three adults spends prolonged periods in sedentary behavior, even though this is associated with a higher risk of chronic disease and premature death. A study in Nature Communications found that higher daily step counts could help offset some of these risks, though not completely for certain heart conditions. Tracking sedentary time Sedentary time refers to waking time spent in low-energy behaviors, such as sitting or reclining. Prior research on reducing the impact of such behavior has largely focused on replacing it with moderate-to-vigorous physical activity (MVPA). However, some studies suggest a high correlation between MVPA and daily steps. Thus, they may show similar associations with disease and mortality risk. The use of commercial wearable sensors and smartphones to track daily step count is a modern innovation that enables such associations to be analyzed more easily. Prior studies suggest additional daily steps Based on prior...

More steps cut chronic disease risk but cannot fully undo long sitting
->News-Medical | More on "Steps reduce sedentary health risks" at BigEarthData.ai | #Disease #Health

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www.france24.com/en/americas/20260409-cal... There isn't the slightest chance of this happening. #Trump is probably clinically #insane & totally unfit to be #POTUS, but his #Cabinet, & the #Republicans, will NEVER move against […]

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#cancer #disease

Take down bird feeders this summer to cut spread of avian disease, says RSPB Garden birds should not be fed seeds and nuts over the summer months, the RSPB has said, in an attempt to reduce the spread of avian diseases. Bird lovers are being urged to take down their bird feeders between May and October to help birds such as the greenfinch, whose numbers have plummeted after the spread of trichomonosis, a parasitic disease transmitted more easily when birds cluster around feeders in the warmer months. In new guidance, the RSPB is advising people to “feed safely and feed seasonally” by removing all bird feeders filled with seeds and peanuts and instead offering small amounts of protein such as mealworms, fat balls or suet from 1 May to 31 October, since they tend not to attract clusters of finches and protein is useful for the birds to feed their chicks. It follows the results of this year’s Big Garden Birdwatch, the world’s largest garden survey with 650,000 participants, which put the greenfinch in 18th place overall. The species, which is now on the red list of endangered British birds, has recorded a 67% decline in average numbers since the annual Big Garden Birdwatch survey began in 1979. An estimated 6 million greenfinches and...

Take down bird feeders this summer to cut spread of avian disease, says RSPB
->The Guardian | More on "Bird feeders avian disease spread" at BigEarthData.ai | #Disease #Health #Bird

Large Language Model–Based Agents for Automated #Research Reproducibility: An Exploratory Evaluation #Study in Alzheimer’s #Disease Date Submitted: Apr 8, 2026. Open Peer Review Period: Apr 9, 2026 - Jun 4, 2026.

Large Language Model–Based Agents for Automated #Research Reproducibility: An Exploratory Evaluation #Study in Alzheimer’s #Disease (preprint) #openscience #PeerReviewMe #PlanP

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#disease #environment

Grant supports community-based approach to heart disease prevention Heart disease and high blood pressure affect millions of Georgians. Yet, for many people, improving heart health has as much to do with finding basic resources - like food, housing and transportation - as it does getting the right medical care. A new five-year, $1.75 million grant from the Merck Foundation to the Georgia Health Policy Center at Georgia State University aims to address these barriers to good heart health by delivering more personal support to people in communities who need it most. Building on what works The Atlanta Regional Collaborative for Health Improvement (ARCHI) is an organization developed by the Georgia Health Policy Center in conjunction with the Atlanta Regional Commission and the United Way of Metro Atlanta. With support from Georgia State, ARCHI brings a care model into Atlanta communities that pairs a patient directly with a community health worker. This health liaison serves as a single point of contact, helping to coordinate care, find services and guide people through the system. "Instead of individuals navigating multiple disconnected services, the responsibility shifts to the system to coordinate support and meet people where they are," says Jeff Smythe, who leads the ARCHI collaborative. Early results of this community health...

Grant supports community-based approach to heart disease prevention
->News-Medical | More on "Community heart disease prevention grants" at BigEarthData.ai | #Disease #Health

#Patients’ Perspectives on Applications of Artificial Intelligence and Personalized #Medicine in Life-Threatening Heart #Disease – PROFID #Patient #Survey #Study Date Submitted: Apr 8, 2026. Open Peer Review Period: Apr 9, 2026 - Jun 4, 2026.

#Patients’ Perspectives on Applications of Artificial Intelligence and Personalized #Medicine in Life-Threatening Heart #Disease – PROFID #Patient #Survey #Study (preprint) #openscience #PeerReviewMe #PlanP

Wildlife trade increases risk of disease transmission to humans From lemurs to fennec foxes, wild animals are bought and sold around the world-legally and illegally, dead and alive-including as pets, for food and for traditional medicinal uses. This global, multibillion-dollar trade is increasing the risk of diseases spreading between animals and humans, according to a new study coauthored by a University of Maryland researcher. The findings from Department of Geographical Sciences Professor Meredith Gore and colleagues at the University of Lausanne in Switzerland were published Thursday in Science. Using four decades of legal and illegal trade data alongside host-pathogen records, the team found that traded wild mammals are 1.5 times more likely to share infectious agents with humans than species not involved in trade. The risk is even higher for animals that are traded illegally or sold live, which is often the case for exotic animals being traded as potential pets. Growing demand for exotic pets, often fueled by social media, has expanded the range of species in circulation, whether otters or sugar gliders. A major outbreak of monkeypox outside Africa, for instance, was linked to a trade in Gambian giant pouched rats and rope squirrels for pets. "Illegal wildlife trade enables novel opportunities for pathogens like these to...

Wildlife trade increases risk of disease transmission to humans
->News-Medical | More on "Wildlife trade disease transmission humans" at BigEarthData.ai | #WildlifeTrade #Disease #Health

#Disease #Science #Research #ArtificialIntelligence
Scientists invented a fake disease. AI told people it was real
www.nature.com/articles/d41...

[...]
Because she works in the medical field, she decided to create a condition related to health and hit on the name bixonimania because it “sounded ...

The Black Death by Thomas Asbridge review – a medieval horror story A magisterial history of one of the worst ever pandemics focuses on the individuals caught up in the chaos

#Disease #Plague #BlackDeath #Pandemic
The Black Death by Thomas Asbridge review – a medieval horror story
www.theguardian.com/books/2026/a...

[...]
And the plague itself, Asbridge argues, was more global than has usually been thought: it was “not solely, or even primarily, a European ...

Illegal and legal wildlife trade fuelling animal-to-human disease transmission, report finds The global wildlife trade — both legal and illegal — is fuelling animal-to-human disease transmission, according to new research published this week. Of the 2,079 mammal species traded worldwide, 41 per cent shared at least one pathogen with humans. In comparison, 6.4 per cent of non-traded mammal species shared human-infecting or "zoonotic" pathogens, according to the report. The research, conducted by a team out of the University of Fribourg in Switzerland, also found traded mammals were about 1.5 times more likely to be hosts of zoonotic diseases. The peer-reviewed report, published in the journal Science on Thursday, local time, noted inter species disease transmission was a "public health priority". '"[But] the long-term impact of the wildlife trade in shaping pathogen exchange between humans and wild animals remains unclear." That transmission, the report said, could happen across all stages of trade — including harvesting, breeding, transport, stockpiling, retail, consumption and companionship. "For instance, a person buying three Finlayson's squirrels in a Laotian wildlife market has been estimated to have an 83 per cent chance of getting at least one leptospirosis-infected [animal]," it said. Every 10 years on the market adds one more pathogen risk Three separate datasets were used to analyse...

Illegal and legal wildlife trade fuelling animal-to-human disease transmission, report finds
->Australian Broadcasting Corporation | More on "Wildlife trade zoonotic disease transmission" at BigEarthData.ai | #WildlifeTrade #Disease #Health

Long COVID associated with higher risk of heart disease Most people who get COVID recover within a few weeks. But for some, symptoms persist for months – a condition now known as long COVID. While it’s often associated with fatigue, breathlessness and “brain fog”, growing evidence suggests it may also affect something less visible, but potentially more serious: the heart. In our recent study, we found that people with long COVID had higher risk of developing cardiovascular disease – including cardiac arrhythmias, heart attack and heart failure. Importantly, the increased risks were seen in people who had never been hospitalised during their initial COVID infection. Much of the early research on long COVID and heart health focused on patients who were hospitalised, particularly those treated in intensive care. These patients often had multiple risk factors for cardiovascular disease such as being overweight and having hypertension or diabetes. This made it difficult to separate the effects of severe acute illness from the long-term effects of the infection. However, the majority of people who had COVID were never admitted to a hospital – yet many still developed chronic symptoms of so-called long COVID. To explore the potential risks in this much larger group, we focused specifically on patients who had experienced...

Long COVID associated with higher risk of heart disease
->The Conversation | More on "Long COVID heart disease risks" at BigEarthData.ai | #Covid #Disease #Health

Adding steps offsets risk of chronic disease: Study Adding as little as 1,700 to 5,500 steps per day can offset the risk of a list of chronic diseases — including obesity, diabetes and sleep apnea — according to a new study from a corresponding author with Vanderbilt Health. The paper, “Daily Steps Offset Risks of Sedentary Behavior in the All of Us Research Program,” was published April 7 in the journal Nature Communications with corresponding author Evan Brittain, MD, MSCI, professor of Medicine. Sedentary behavior has been associated with chronic mortality and chronic diseases. The study’s authors found that greater sedentary time was associated with higher risk of obesity, diabetes mellitus, hypertension, coronary artery disease, heart failure, chronic kidney disease, metabolic dysfunction-associated steatotic liver disease (MASLD), chronic obstructive pulmonary disease (COPD), major depressive disorder, sleep apnea and atrial fibrillation. Researchers set out to discover how many additional steps patients need to reduce those risks. Researchers looked at 15,327 adult participants who used a Fitbit, a wearable electronic activity tracker that counts steps, as part of the NIH’s All of Us precision medicine research initiative. That database includes nearly 1 million people in the United States who share multiple longitudinal data points, including electronic health records, physical measures and...

Adding steps offsets risk of chronic disease: Study
->Newswise | More on "Steps reducing chronic disease risk" at BigEarthData.ai | #Disease #Health

How variant discovery redefines genetic prevalence: the case of cystine stone disease Cystine stone disease is a monogenic disorder resulting from cystinuria, a hereditary metabolic defect characterized by the excessive excretion of cystine in the urine [1]. Cystinuria arises from a defective transport system of the dibasic amino acids in the renal tubules causing cystine reabsorption failure [2]. Coupled with the insolubility of cystine in lower urine pH [3], cystinuria promotes stone formation and is responsible for 1-2% of all kidney stones and 10% of all kidney stones in children [4]. Cystinuria represents the most common cause of monogenic kidney stone disease [5]. Patients suffer from recurrent stone formation and renal insufficiency even with treatment [4, 6, 7]. Cystinuria has a global clinical prevalence of 1 in 7,000 [8]. The genetic etiology of cystinuria is associated with two causal genes [8]. The two genes are SLC3A1, located on chromosome 2p21, encoding the heavy subunit rBAT of a renal b(0,+) transporter, and SLC7A9, located on chromosome 19q12, encoding its interacting light subunit b(0, + )AT [8,9,10]. The classification system divides cystinuria into three subtypes based on genetic etiology: type A, caused by pathogenic SLC3A1 variants; type B, by pathogenic SLC7A9 variants, and putative type AB, by pathogenic SLC3A1 and SLC7A9 variants [11]. Epidemiological...

How variant discovery redefines genetic prevalence: the case of cystine stone disease
->Nature | More on "Genetic variants in cystine disease" at BigEarthData.ai | #Disease #Health

Mount Sinai Researchers Develop Machine Learning Model to Predict How CPAP Affects Cardiovascular Disease Risk in Patients With Obstructive Sleep Apnea Stacy A. Anderson Mount Sinai Press Office 347-346-3390 stacy.anderson@mountsinai.org Mount Sinai Researchers Develop Machine Learning Model to Predict How CPAP Affects Cardiovascular Disease Risk in Patients With Obstructive Sleep Apnea (New York, NY – April 9, 2026) – Mount Sinai researchers have created an analytic tool using machine learning that can predict cardiovascular disease risk in millions of patients with obstructive sleep apnea, a serious sleep disorder, according to findings recently published in Communications Medicine. The team said their study is the first to provide estimates of whether continuous positive airway pressure (CPAP), a widely used therapy for obstructive sleep apnea, will increase or decrease an individual’s cardiovascular risk. It highlights the potential for precision medicine and varied approaches to tailor clinical care and reduce cardiovascular disease risk in vulnerable patients. Obstructive sleep apnea is a common, serious condition in which breathing repeatedly stops and starts during sleep. It affects an estimated 25 million people in the United States, and is associated with elevated risks for cardiovascular disease, including stroke and heart disease. CPAP, which provides a continuous stream of pressurized air through a mask and helps eliminate breathing disturbances during sleep, remains the most effective treatment for sleep apnea...

Mount Sinai Researchers Develop Machine Learning Model to Predict How CPAP Affects Cardiovascular Disease Risk in Patients With Obstructive Sleep Apnea
->Newswise | More on "CPAP sleep apnea cardiovascular prediction" at BigEarthData.ai | #Disease #Health #MachineLearning

Find out the relationship between mosquitoes, malaria and nutrition at beyondosaurus.com/malaria ( #malaria, #mosquitoes, #mosquito, #nutrition, #insect, #disease, #nutritional, #food)

Animals on wildlife market more likely to carry human-infecting disease, report finds Of the 2,079 mammal species traded worldwide, 41 per cent share at least one pathogen with humans, according to new data released today.  #disease #outbreak #health #animals

Of the 2,079 mammal species traded worldwide, 41 per cent share at least one pathogen with humans, according to new data released today.  #disease #outbreak #health #animals

Sea-level rise is a health crisis and we must hold polluters accountable | Christiana Figueres Those facing the earliest and harshest consequences are, overwhelmingly, those who did the least to create them

#Health
#SeaLevelRise
#Food
#Water
#Disease
#OceanHeat
#Cryosphere
#ThermalExpansion
#StormSurge
#KingTides
#CoastalFlooding
#CoastalErosion
#SaltWaterIntrusion
#LandSubsidence
#RiverDeltas
#Infrastructure
#HumanDisplacement
#Oil
#Coal
#Gas
#FossilFuelPollution
#AnthropogenicGlobalWarming

Sea-level rise is a health crisis and we must hold polluters accountable | Christiana Figueres Those facing the earliest and harshest consequences are, overwhelmingly, those who did the least to create them

#SeaLevelRise
#OceanHeat
#Cryosphere
#ThermalExpansion
#StormSurge
#KingTides
#CoastalFlooding
#CoastalErosion
#SaltWaterIntrusion
#LandSubsidence
#RiverDeltas
#Food
#Water
#Health
#Disease
#Infrastructure
#HumanDisplacement
#Oil
#Coal
#Gas
#FossilFuelPollution
#AnthropogenicGlobalWarming

Kidney disease is growing in Africa: big new study casts light on genetic risk factors Every minute your kidneys are hard at work, filtering around 200 litres of blood, removing waste, balancing salts and fluids, and regulating blood pressure. This happens without any conscious effort on your part. But when your kidneys begin to fail, the consequences are devastating, including fatigue, fluid buildup and heart complications. Some people eventually need dialysis or a transplant to stay alive. Kidney disease is one of the fastest-growing causes of death across the world. Around 850 million people are living with some form of it, more than the combined number of people affected by diabetes and cancer. Chronic kidney disease – when your kidneys slowly lose the ability to do their job – causes approximately 1.5 million deaths each year globally and that toll is rising. But kidney disease develops silently, with few symptoms until it is already severe. And the burden is not shared equally. People of African ancestry are four times more likely to develop the most severe form of kidney failure than people of European ancestry. In sub-Saharan Africa, rates of high blood pressure and type 2 diabetes are rising too. Both are leading drivers of kidney damage. Around 30% of adults in sub-Saharan Africa have...

Kidney disease is growing in Africa: big new study casts light on genetic risk factors
->The Conversation | More on "African kidney disease genetic research" at BigEarthData.ai | #Disease #Health

How the wildlife trade boosts the chance of a disease jumping from animals to humans The wildlife trade is expansive. Whether legal or not, it encompasses pet sales, meat markets, furs and even medicine. About 25 percent of mammal species are involved in some part of the trade, and scientists have warned that it may contribute to zoonotic diseases—illnesses that arise from pathogens that jump from animals to humans, as had occurred with the virus that causes COVID. But exactly how and how often these diseases are passed from animals to humans isn’t always clear. A new study published today in Science reveals a close correlation between species in the wildlife trade and animals that are known to have passed pathogens on to humans. “There’s a strong link,” says Jérôme Gippet, an ecologist at the University of Fribourg in Switzerland. “What we could calculate is that, for every 10 years that the species is on the wildlife market, it shares one additional pathogen with humans.” On supporting science journalism If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today. The researchers combed through more than 40 years of data tracing...

How the wildlife trade boosts the chance of a disease jumping from animals to humans
->Scientific American | More on "Wildlife trade zoonotic disease risk" at BigEarthData.ai | #WildlifeTrade #Disease #Health

One woman, three autoimmune diseases: CAR-T therapy vanquishes ultra-rare disease trio A woman with an ultra-rare combination of three autoimmune diseases has had no symptoms since receiving a single dose of engineered immune cells, doctors in Germany report today1. She had previously received nine other types of treatment without getting better, could no longer work and was sometimes bedridden for weeks with pain and fatigue. “Her disease got completely out of hand” and became “very life-threatening”, says Fabian Müller, a haematologist at University Hospital Erlangen in Germany who helped to treat her and co-authored the report. Without the engineered cells, the woman, who was 47 when she met Müller and his colleagues, would have had a “terrible” quality of life, says Carl June, an immunologist at the University of Pennsylvania in Philadelphia who pioneered the use of similar cells to treat cancer, “if she would even be alive.” Rogue B cells The woman’s trifecta of autoimmune diseases stemmed from problems with her B cells, a type of immune cell. Her B cells were making antibodies that mistakenly attacked her own red blood cells, causing the disease autoimmune haemolytic anaemia. They also attacked her platelets, causing immune thrombocytopenia, and some fat-binding proteins, causing antiphospholipid syndrome. Turbocharged ‘killer’ cells show promise for autoimmune...

One woman, three autoimmune diseases: CAR-T therapy vanquishes ultra-rare disease trio
->Nature | More on "CAR-T therapy autoimmune breakthrough" at BigEarthData.ai | #Disease #Health

Lyme disease is spreading, but a new vaccine could curb infections Since pharmaceutical companies Pfizer and Valneva announced positive results from their phase 3 trial of a vaccine to prevent Lyme disease last month, two questions have loomed large: Will the vaccine receive approval from the Food and Drug Administration. And if so, will the U.S. public accept it? An effective vaccine could put a huge dent in the growing burden of Lyme disease. Populations of the ticks that spread the disease are growing, and nearly a half-million estimated cases of Lyme disease occur in the U.S each year. But the vaccine must overcome the same obstacles that caused an earlier Lyme vaccine to be pulled from the market in 2002. The recent announcement showed the vaccine was capable of preventing Lyme disease infection. But its efficacy was only about 73 to 75 percent. The trial also faced several setbacks, including quality concerns that led Pfizer to drop about half the study population several years ago. The results also were not as statistically powerful because fewer infections occurred than expected in the placebo group during the trial. Still, clinicians are approaching the latest news with cautious optimism. “I do think this is great news,” says Martin Backer, an infectious disease physician...

Lyme disease is spreading, but a new vaccine could curb infections
->Scientific American | More on "Lyme disease vaccine FDA approval" at BigEarthData.ai | #Vaccine #Infection #Disease #Health

Effects of a Personalized Retrieval-Augmented Generation Chatbot on Information Needs in Chronic Kidney #Disease #Patients: Mixed Methods #RCT #ClinicalTrial Date Submitted: Apr 7, 2026. Open Peer Review Period: Apr 8, 2026 - Jun 3, 2026.

Effects of a Personalized Retrieval-Augmented Generation Chatbot on Information Needs in Chronic Kidney #Disease #Patients: Mixed Methods #RCT #ClinicalTrial (preprint) #openscience #PeerReviewMe #PlanP

Shrimp virus jumps to humans, causing rare eye disease in China A virus normally found in marine animals such as shrimp and fish has now been linked to a chronic eye disease in humans, according to a new study published in the journal Nature Microbiology. Scientists say the discovery could help explain a mysterious eye condition that has been rising in parts of China in recent years. The disease, called persistent ocular hypertension viral anterior uveitis (POH-VAU), causes severe inflammation in the eye and dangerously high eye pressure. If untreated, it can damage the optic nerve and threaten vision. A MYSTERY EYE DISEASE Doctors had been puzzled by the growing number of cases. People with the condition repeatedly tested negative for common viruses known to infect the eye, such as herpes or shingles. But researchers noticed something unusual when examining eye tissue from some patients. Under the microscope, they saw tiny virus-like particles that looked very similar to covert mortality nodavirus (CMNV) — a virus usually found in aquatic animals like shrimp. This raised an important question: Could a virus from the sea be infecting humans? WHAT THE SCIENTISTS FOUND To investigate, researchers studied 70 patients diagnosed with the condition between January 2022 and April 2025. During eye surgeries, they collected...

Shrimp virus jumps to humans, causing rare eye disease in China
->India Today | More on "Shrimp virus causes human eye disease" at BigEarthData.ai | #Disease #Virus #Health

Thank you to @HCneuro for awarding our lab a #2025 #pilot #award to examine the role of #adaptive #immune #system in #Parkinson #Disease @WashUNeurology hopecenter.wustl.edu/funding-awar...

Ralph M Larmann, Gothic America, 2013. Acrylic on canvas, 36 x 48 inches. Courtesy of the artist. #art #painting #artsky #Gothic #America #Evangelicalindustrialcomplex #smokestacks #Ralph #Larmann #Swope #TerreHaute #Indiana #dark #DarkAges #landscape #darksky #joylessness #poverty #famine #disease