Evolution tunes functional sub-state interconversion to boost enzyme function Enzymes do not operate as static structures, but continuously fluctuate between different conformations. Enzymes therefore dynamically sample conformations with varying catalytic activity. However, it...

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Enzyme function does not rely only on static structure 🧩, but also on the rate at which functional sub-states interconvert ⏱️, making this interconversion subject to natural selection 🧬.

#OXA-48 #ceftazidime #enzymeevolution

www.biorxiv.org/content/10.6...

Unlocking the Secrets of Cold-Adapted Enzymes Researchers from Waseda University reveal how enzymes evolve to function in freezing conditions—unlocking potential for breakthroughs in biotech and medicine.

Discover how cold-adapted enzymes revolutionize biotechnology and medicine by thriving in freezing temperatures. #Biotech #EnzymeEvolution #ColdAdaptation