Structural role of conformational heterogeneity and juxtamembrane regions in the Ephrin A1 interactions with the EphA2 receptor ligand-binding domain Ephrin growth factors are attached to the membrane by either GPI-anchor or transmembrane domains and are known to signal bi-directionally: cells, expr…

Our study shows Ephrin A1 undergoes conformational selection when binding EphA2, while its juxtamembrane regions stay flexible. These insights clarify bidirectional signaling and may guide future therapeutic strategies.
Full text: www.sciencedirect.com/science/arti...

#NMR #Ephrin #Cancer #receptor

The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging - Nature Medicine The largest harmonized proteomic dataset of plasma, serum and cerebrospinal fluid samples across major neurodegenerative diseases reveals both disease-specific and transdiagnostic proteomic…

At IPI, we’re building #antibodies to explore neurodegenerative targets, including #Ephrin & #Semaphorin. That’s why we’re excited by a landmark data set from @neuroproteome.bsky.social revealing #proteomic signatures in Alzheimer’s, Parkinson’s & more.

Take a look! www.nature.com/articles/s41...

The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging - Nature Medicine The largest harmonized proteomic dataset of plasma, serum and cerebrospinal fluid samples across major neurodegenerative diseases reveals both disease-specific and transdiagnostic proteomic…

The @neuroproteome.bsky.social has released 250M protein measurements from 35K+ samples, revealing #proteomic signatures in Alzheimer’s, Parkinson’s & more. At IPI, we’re building #antibodies to explore some of the targets, including #Ephrin & #Semaphorin. Read more: www.nature.com/articles/s41...