New paper! 🎉 Efficient one-step enzymatic synthesis of cyclic-2,3-diphosphoglycerate (cDPG) — an extremolyte from archaea!
Congrats to Christina + HotSolute team!
#ArchaeaSky #Extremozymes #Archaea #ERACoBioTech #Horizon2020
www.frontiersin.org/articles/10....

A stable GH31 α-glucosidase as a model system for the study of mutations leading to human glycogen storage disease type II GH31 glycosidases are widespread across organisms, but remarkably, less than 1% of them have been biochemically characterised to date. Among them, human lysosomal acid α-glucosidase (GAA) stands ou...

Our latest paper is out!
We explored MalA, a hyperthermostable GH31 α-glucosidase, as a model to study Pompe disease mutations & chaperone therapy.

Check it out: www.tandfonline.com/doi/full/10....

#PompeDisease #Biochemistry #Glycosidases #EnzymeTherapy #Extremozymes #CAZymes