Here you can see a cryoEM structure of human FAN1 protein in complex with 5' flap DNA substrate (PDB code: 9EO1)
Rendering by Francisco J. Enguita made with #ProteinImager
3dproteinimaging.com/protein-imag...
#SciArt #molecularart #fanconi #dna #huntington #cryoem
#FANCONI 💣🐚💣🐚💣🐚
Heard that story about #Trump wearing pee bag???
But what's the big deal if he has this disease? 🤔
Trump actually did some good things for #kidneyresearch in 2019, why!?!?
#RFS #RenalFanconiSyndrome #Foleycatheter
#DrBornstein 💀 1/8/2021
Impactante, emotivo y veraz testimonio de Paula Seoane, madre de Xabi, un niño con Anemia de #Fanconi que relata todos y cada uno de los pasos transitados desde conseguir el diagnóstico genético hasta ser candidato para la terapia génica propuesta por Juan Bueren y Paula Rio.
La primera iniciativa que comentamos hoy en #investigaresavanzar está dedicada a la Anemia de #Fanconi con la presencia de Paula Río #CIEMAT Alicia de las Heras, Fundación Anemia de Fanconi y la madre de Xavi, niño con AF que ha recibido la terapia génica desarrollada en el #CIBERER
Haematopoietic gene therapy of non-conditioned patients with #Fanconi #anaemia-A: results from open-label phase 1/2 (FANCOLEN-1) and long-term clinical trials www.sciencedirect.com/science/arti... #hvhebron #ohp
Structural and biochemical basis of FANCI-FANCD2 interdependent ubiquitination from @hw1o9. Another pretty cryo-EM structure and some new data on ubiquitination within the #Fanconi #DNArepair pathway.
www.biorxiv.org/content/10.1101/2022.04....
Global and disease-associated genetic variation in the human #Fanconi anemia gene family http://goo.gl/ShqIfA
Targeted gene therapy for correction of bone marrow defect in #Fanconi anemia. Exciting step forward!
http://goo.gl/5YMQYk
FANCC knockout worsens the phenotype of a mouse model of replication origin depletion. Relevance to #Fanconi anemia? http://goo.gl/vgR3tM
An inspirational story from an Australian mother of a child with #Fanconi anemia. http://goo.gl/EKZOIs
Finally: our structure of FANCM:FAAP24 is online today @Structure_CP http://goo.gl/cimq86 #Fanconi pdb:4BXO
Further structural characterisation of MHF1:2 aka CENP-S/X reveals octomer bound to FANCM http://goo.gl/hswzYe #Fanconi
Two new #Fanconi anemia related papers advance online at Nucleic Acids Research:
http://goo.gl/aJiWe
http://goo.gl/e2UPA
An Alan D'Andrea review that doesn't mention the word #Fanconi once? What the...? http://goo.gl/NwuhL
