Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation - PubMed Factor H (FH) is a negative regulator of the alternative pathway (AP) of complement however, five human factor H-related (FHR) proteins, can also function ex vivo as positive regulators. We compare…

Interesting to see that FHR proteins have now been found to accumulate in the synovial lining in rheumatoid arthritis, co-localising with C3. Study concluded that FHRs (mainly FHR3) may be driving complement activation. #complement #RA #FHRs buff.ly/b3hOgIX

Factor H-related 1 and heparan sulfate architecture contribute to complement dysregulation in C3 glomerulopathy - PubMed Altogether, we show that as renal function declines, a change in the FHR-1:FH ratio combined with changes in heparan sulfate architecture increase complement activity. These findings suggest that…

Altered heparan sulphate architecture causes FHR-1 to disrupt FH function, increasing complement activation on mesangial cells. This is similar to how GAG changes in the blood/retinal barrier affect complement activity. #GAGs #FHRs #complement buff.ly/No5uT9h

FINAL CALL! The FHRS application deadline is TONIGHT at midnight ET!

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Factor H-related 2 levels dictate FHR dimer composition - PubMed Factor H-related (FHR) protein 1 and 2 form dimers resulting in FHR-1 and -2 homodimers, and FHR-1/2 heterodimers. Dimerization is hypothesized to further increase their antagonistic function with…

Circulating levels of FHR-2 may influence the dimerization states of FHR proteins. This is important as it may impact their biological effects on surfaces more than previously thought. #FHRs #complement #AMD buff.ly/aazRWVT

Time is running out! Just 3 days left to apply for FHRS and to be considered for induction at Heart Rhythm 2025 in San Diego!

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Will you be on stage at this year's FHRS induction ceremony at #HRS2025? Apply by March 31, 2025, and take your place among leaders in the field.

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Elevated Plasma Complement Factors in CRB1-Associated Inherited Retinal Dystrophies - PubMed CRB1-IRDs are characterized by changes in plasma levels of complement factors and proteins of the innate immune system, and linkage between CRB1 and CFH genes implicates functional variants of the…

Significant elevated levels of FHR-2 in the blood of patients suffering CRB1-associated inherited retinal dystrophies. I wonder if FHR-2 accumulates in the back of the eye in these patients like it does for AMD? #complement #FHRs https://buff.ly/3Qs1i6y

Guidance in England that to display an incorrect sticker may be an offence under trading standards legislation for example an offence under the Consumer Protection from Unfair Trading Regulations 2008.

www.food.gov.uk/sites/defaul... Food Hygiene Rating Scheme%3B Guidance on implementation and operation - the Brand Standard.pdf

Possible offence to display incorrect #FHRS sticker

"Consumer Protection from Unfair Trading Regulations 2008" enforced by #tradingstandards

#levelplayingfield

The investigation raises questions about the effectiveness of England's voluntary display system for food hygiene ratings. Unlike in Wales and Northern Ireland, where displaying a rating is mandatory, English establishments can lawfully choose whether or not to show their ratings - or even display false ones. … The Food Standards Agency said displaying incorrect ratings was potentially illegal. It said its latest audit showed 91% of English businesses displayed the correct ratings, adding that it had long advocated for making the scheme statutory in England – as it is in Wales and Northern Ireland – but that the final decision about that was one for the government.

Food rating lies exposed by BBC secret recording www.bbc.co.uk/news/article...

The UK Food Standards Agency's food hygiene rating data ratings.food.gov.uk/open-data + search for ratings ratings.food.gov.uk

#FHRS #foodhygiene #foodsafety #opendata

The BBC's analysis of more than 250,000 public records on the Food Standards Agency website has found more than 53,000 had not been inspected since 2021. In Scotland, which runs a pass or fail food hygiene scheme, nearly 40% of businesses were last assessed more than two years ago. Emily Miles, the chief executive of the Food Standards Agency, which oversees food hygiene inspections in England, Wales and Northern Ireland, said councils were generally getting through backlogs of high-risk inspections, which mounted during the Covid lockdowns. But she said the agency was concerned lower-risk venues and new venues were not being checked.

Delays in #foodhygiene inspections a 'serious #publichealth issue' www.bbc.co.uk/news/article...

The Food Standards Agency's UK food hygiene rating data ratings.food.gov.uk/open-data + search ratings.food.gov.uk

#FHRS /FHIS #foodsafety #localgov #opendata #ddj

Survey on the Food Hygiene Rating Scheme - please take a look and complete. Takes less than 5 minutes to complete.

#FoodHygiene #Food #Hygiene #FHRS #FoodSafety

surveymonkey.co.uk/r/EPQMSH578

Thinking About Food Hygiene Thanks to COVID-19 many of us have faced lockdowns and other restrictions. That has meant less eating out – even if there has been the occasional take-away (and of course we’ve still be…

Thinking About Food Hygiene

#FoodHygiene #Food #Hygiene #FHRS #Education #Restaurant #EatOut #FoodDelivery #TakeAway #TakeOut #FSA #FoodStandards #Research #EPQ #Survey #Hygiene101 #FoodSafety #UK

hoodcp.wordpress.com/2021/03/30/thi…

Please aid with some research about the Food Hygiene Rating System that my daughter is doing at high school by taking part in a short survey.#FoodHygiene #Food #Hygiene #FHRS #Education #Research #EPQ #Survey #Hygiene101 #FoodSafety #UK

surveymonkey.co.uk/r/EPQMSH578