Survey Shows AI Adoption Is Growing in Transfusion Medicine Nearly half of ISBT members reported personal AI use, with most citing positive impact on transfusion medicine, including FNAIT.

Artificial intelligence (#AI) is gaining traction in transfusion medicine, including applications relevant to fetal and neonatal alloimmune thrombocytopenia (#FNAIT). Study in Vox Sanguinis.

Learn more: https://bit.ly/404ndpl

#RareDisease #MedTech #TransfusionMedicine

FNAIT Associated With Childhood Neuropsychiatric Disorders FNAIT can lead to intracranial hemorrhage, which can increase the risk of various developmental delays later in childhood, according to recent research.

#SMFM2026: A history of #FNAIT is associated with mental, emotional, behavioral, and developmental (#MEBD) disorders, making medical surveillance an imperative. Presented at 2026 Society for Maternal Fetal Medicine Pregnancy Meeting.

Read here: https://bit.ly/4aHG8MC

#RareDisease #MedSky

Rare Patient Voice rewards patients and caregivers for sharing their insights Recruitment company Rare Patient Voice has more than 200,000 registered patients and family caregivers spanning rare, chronic and complex conditions.

Recruitment company @rarepatientvoice.bsky.social has more than 200,000 registered patients and family caregivers spanning rare, chronic and complex conditions.

Check out this latest feature from FNAIT Companion: https://bit.ly/4tvE1TM

#RareDiseaseMonth #RareDisease #MedSky #FNAIT

Beautiful day at Albert Park Lake, as part of Run for Rui, raising money for research into fetomaternal/neonatal alloimmune thrombocytopenia, #FNAIT.
Funds will support the vital work of the Australian NAIT Registry.
Please support us if you can!
sleapys-foundation.grassrootz.com/run-for-rui

Mind-Body, Aerobic Exercises Help Counter Perinatal Psychiatric Morbidity Recent research has shown that mind-body and aerobic exercises may play a significant role in alleviating perinatal depression and anxiety.

Mind-body and aerobic exercise can be useful in countering #PerinatalDepression and anxiety. #FNAIT is known to be a significant risk factor for poor maternal psychological outcomes.

Read more: https://bit.ly/3Ma4EfU

#RareDisease #MedSky

New Genome-Editing Platform for Classifying Genetic Variants Linked to Platelet Disorders The system, known as CRIMSON HD, is applicable to CD34+ cell-derived blood lineages and has been optimized for assessing platelet-linked variants.

Researchers have designed a new genome-editing platform to functionally classify genetic variants associated with inherited platelet disorders such as fetal and neonatal alloimmune thrombocytopenia (#FNAIT). @ajhgnews.bsky.social

Read here: https://bit.ly/4r2zlSX

#RareDisease #MedSky

Global Pediatric ICH Cases Fall But Remain a Significant Public Health Concern Research shows that despite a decrease in cases of pediatric ICH over the last 3 decades, it remains a significant public health concern.

Although the rate of pediatric intracranial hemorrhage (#ICH) cases has decreased over the years, it remains a significant public health concern

Fetal and neonatal alloimmune thrombocytopenia (#FNAIT) is a major risk factor for #NeonatalICH.

Read more: https://bit.ly/49o4pp1

Platelet-Activating Anti-HPA-1a Antibodies Drive Pathogenic Mechanisms in FNAIT Only the M-204 anti-HPA-1a antibody triggered FcγRIIa-dependent platelet activation, indicating functional heterogeneity relevant to the severity of FNAIT.

#FNAIT is a potentially life-threatening condition with a distinct subset of HPA-1a antibodies that can directly activate platelets through FcγRIIa. Presented at #ASH2025, from @rarediseaseadvisor.bsky.social.

https://bit.ly/4b8SlKS

#ASH25

Simulation-Based Training Linked to Optimized Emergency Care by Obstetric Nurses Simulation-based training has been associated with significantly enhanced preparedness on the part of maternity nurses.

Using a 2-day in-house educational intervention, with combined lectures and simulations, significantly improved nurses’ self-assessed competencies, practical skills, and confidence in managing #EmergencyObstetrics situations.

Learn more: https://bit.ly/48xlkqg

#RareDisease #FNAIT #HDFN #Obstetrics

Immune-Modulating Therapy Achieves Successful Pregnancies in CIUE With FNAIT-Like Injury Chronic histiocytic intervillositis of unknown etiology in the context of FNAIT-like fetal-specific anti-HLA responses responded to a transplant-derived immunosuppressive regimen.

Reversal of recurrent pregnancy loss associated with CIUE was achieved through an immunosuppressive protocol directed at antibody-mediated alloimmunity, a mechanism closely related to that seen in #FNAIT. From @frontiersin.bsky.social and @rarediseaseadvisor.bsky.social.

https://bit.ly/4ixvbzs

Platelet-Activating Anti-HPA-1a Antibodies Drive Pathogenic Mechanisms in FNAIT According to recent research, a subset of anti-HPA-1a antibodies directly activated human platelets via FcγRIIa, suggesting added pathogenicity in FNAIT.

Fetal and neonatal alloimmune thrombocytopenia (#FNAIT) is a potentially life-threatening condition with a distinct subset of antihuman platelet antigen 1a antibodies that can directly activate platelets through #FcγRIIa. @ash.hematology.org

Read more: https://bit.ly/3Y3qgwK

#RareDisease #ASH25

Diversity of Anti-HPA-1a Antibodies Offers New Insight Into FNAIT Pathology The diversity of HPA antibodies, associated with variations in epitope specificity and functional effects, can make it difficult to predict FNAIT severity.

Among patients with #FNAIT, antihuman platelet antigen antibodies exhibit functional heterogeneity, which can lead to difficulties in predicting disease severity.

Learn more: https://bit.ly/3M1dM6f

#RareDisease #MedSky

FNAIT Severity Determined by Anti-HPA-1a Antibody Reactivity, Integrin Conformation New research suggests FNAIT severity is driven by overall anti-HPA-1a antibody reactivity and integrin conformation, not exclusive endothelial targeting.

The severity of #FNAIT is driven by overall antihuman platelet antigen 1a (HPA-1a) antibody reactivity and integrin conformation rather than exclusive endothelial targeting. Study in @bloodjournals.hematology.org

Read more: https://bit.ly/3JJDJql

#RareDisease #Hematology #HPA1a #MedSky

HLA Genotyping Guides Safe FNAIT Risk Assessment and Maternal Care HLA genotyping enables precise identification of HPA-1bb pregnant women at negligible risk for FNAIT, reducing unnecessary intervention.

Human leukocyte antigen (#HLA) genotyping enhances the prediction and prevention of fetal and neonatal alloimmune thrombocytopenia (#FNAIT), allowing clinicians to identify #Pregnancies at minimal risk and avoid unnecessary interventions.

Read more: https://bit.ly/4oFulTN

#RareDisease #MedSky

Prophylaxis With IVIG and Emerging Therapies Transform FNAIT Management Immunoglobulin prophylaxis remains the most effective treatment to prevent severe FNAIT, although emerging drugs may soon replace it.

#Prophylaxis with #IVIG remains the most effective intervention to prevent severe bleeding complications in #FNAIT, although pharmacologic inhibitors of placental IgG transport are under investigation and may supplant IVIG in the future.

Learn more: https://bit.ly/476owIJ

#RareDisease #MedSky

NGS Enables Reliable Noninvasive Genotyping for Fetal Blood Group Incompatibilities Next-generation sequencing provided accurate, noninvasive genotyping of fetal blood group antigens, reducing the risk of false-negative results.

Next-generation sequencing (#NGS) is a reliable method for noninvasive fetal blood group genotyping, with direct implications for preventing complications such as #FNAIT and #HDFN.

Read more: https://bit.ly/48re6o2

#RareDisease #MedSky #RareSky

Proud to announce the safe delivery of the first UK baby whose mother took part in the #FREESIA-3 study! This open label randomised phase 3 trial investigates Nipocalimab vs ivig in women previously affected by #FNAIT
buff.ly/m3YV734
#ClinicalStudies #ClinicalResearchGroup #OUH #FetalMedicine

FNAIT Identified as a Notable Cause in Some Cases of Prenatal Intracranial Hemorrhage FNAIT was identified as one of the potential causes of nonobvious prenatal intracranial hemorrhage discovered using ultrasound and MRI.

New research into prenatally diagnosed intracranial hemorrhage (#ICH) presented at the 2025 @isuog.bsky.social World Congress revealed fetal and neonatal alloimmune thrombocytopenia (#FNAIT) as one of the identifiable causes.

Read more: https://bit.ly/42EEDue

#RareSky #MedSky

FREESIA-3 Study Adds First US Site The study is recruiting up to 50 participants to assess the efficacy and safety of nipocalimab in reducing the risk of severe FNAIT.

Philadelphia @pennmedicine.bsky.social has been added as a site for the #FREESIA3 trial investigating #Nipocalimab vs intravenous immunoglobulin (#IVIG) in pregnancies at risk of fetal and neonatal alloimmune thrombocytopenia (#FNAIT).

Read more: https://bit.ly/4mZjRhb

#RareSky #MedSky