Advanced Lung Function Measurement In A Novel HIV/TB Co-infection in Mouse Models Tuberculosis and Human Immunodeficiency Virus are major global health threats. Their interaction worsens disease severity, as HIV reduces CD4+ T cells, making individuals more vulnerable to TB.

This blog discusses a study by Bohorquez et al. (2024) who developed a humanized NSG-SGM3 mouse model to advance HIV/TB co-infection studies, a model that has been lacking in co-infection research. Full blog: hubs.ly/Q03tNQGM0

#flexiVent #flexiVentLungFunction #TB #Tuberculosis #HIV

Treating Acute Inflammatory Lung Disease: The Promise of Trimannose-Coupled antimiR-21 Recent advances in the fight against severe acute inflammatory lung diseases, including COVID-19, have revealed a promising new approach to treating pulmonary hyperinflammation and long-term lung dama...

This recent blog features a study by Beck et al (2023) which developed a first-in-class, carbohydrate-coupled inhibitor of microRNA-21 (RCS-21), that shows significant potential as a therapeutic agent: www.scireq.com/treating-acu...

#LungFunction #FlexiVent #SCIREQ

Role of Paraoxonase 2 in Airway Epithelial Response to Oxidant Stress Asthma is a widespread chronic lung disease characterized by airway inflammation and hyperresponsiveness. This airway inflammation is classified by either the presence (T2-high) or absence (T2-low) of...

A new study published in Antioxidants sheds light on the role of Paraoxonase 2 (PON2) in defending airway epithelial cells against oxidant stress, offering potential insights for managing T2-low asthma—a challenging subtype with limited treatment options. www.mdpi.com/2076-3921/13... #flexiVent

Ficolin-1 ameliorates pulmonary fibrosis via directly binding to TGF-β1 - Journal of Translational Medicine Background Ficolins were originally identified as proteins that bind to transforming growth factor-β1 (TGF-β1). They are capable of activating the complement system through lectin pathway for immune s...

A new study in the Journal of Translational Medicine highlights how ficolin-1 may revolutionize treatment for fibrotic lung diseases. Using advanced tools in the #flexiVent researchers discovered that it directly binds to TGF-β1, significantly reducing its harmful effects: hubs.ly/Q02-XcmJ0

New Methodology: Analyzing Volatile Organic Compounds With The flexiVent System Volatile organic compounds (VOCs) in breath are emerging as vital biomarkers in medical research, offering a non-invasive glimpse into metabolic and physiological processes. A recent publication by Ta...

Recent publications by @owlstonemedical.bsky.social Medical introduce a novel method for capturing VOCs from the breath of intubated mouse models that integrates advanced sorbent tube technology with the #flexiVent system.

Read more in the full blog: hubs.ly/Q031fHCS0