Frontiers | Mass spectrometry-based analysis of rheumatoid factor IntroductionRheumatoid factor (RF) are autoantibodies that are found in approximately two thirds of patients with rheumatoid arthritis, a chronic autoimmune ...

Mass spectrometry-based analysis of rheumatoid factor #FrontImmunol www.frontiersin.org/journals/imm...

Frontiers | Mechanisms underlying the mitigating action of Maxing Shigan Decoction in acute lung injury caused by influenza virus based on UPLC-HRMS analysis and network pharmacology IntroductionInfluenza A virus (IAV) infection is associated with high morbidity and mortality and can ultimately lead to acute lung injury (ALI). In traditio...

Mechanisms underlying the mitigating action of Maxing Shigan Decoction in acute lung injury caused by influenza virus based on UPLC-HRMS analysis and network pharmacology #FrontImmunol www.frontiersin.org/journals/imm...

Frontiers | Metabolomic insights into variable antihistamine responses in allergic rhinitis: unveiling biomarkers for precision treatment BackgroundThe clinical response to antihistamine therapy exhibits substantial heterogeneity among individuals with allergic rhinitis (AR). While these medica...

Metabolomic insights into variable antihistamine responses in allergic rhinitis: unveiling biomarkers for precision treatment #FrontImmunol #MassSpec www.frontiersin.org/journals/imm...

Frontiers | Distinct metabolomic signatures in allergic rhinitis with concurrent chronic spontaneous urticaria: an untargeted metabolomics analysis reveals novel biomarkers and pathway alterations BackgroundAlthough allergic rhinitis (AR) and chronic spontaneous urticaria (CSU) share overlapping immunological pathways, their distinct clinical manifesta...

Distinct metabolomic signatures in allergic rhinitis with concurrent chronic spontaneous urticaria: an untargeted metabolomics analysis reveals novel biomarkers and pathway alterations #FrontImmunol #MassSpec www.frontiersin.org/journals/imm...

Frontiers | Proteomic and metabolomic analysis of serum in women infected with COVID-19 during late pregnancy IntroductionTo investigate the alterations of serum proteins and metabolomics in women infected with severe acute respiratory syndrome coronavirus 2 (SARS-Co...

Proteomic and metabolomic analysis of serum in women infected with COVID-19 during late pregnancy #FrontImmunol #MassSpec www.frontiersin.org/journals/imm...

#Sepsis

Opsonic peptide 18/OP18
DAMP scavenger against eCIRP HMGB1 Histone H3

15aa multi-DAMP-binding peptide of TLR4 + RGD peptide

⏫Mφ internalization of DAMPs
⏬DAMP-induced Mφ release of TNFα
⏫OXPHOS
⏬Lung Cytokine Apoptosis
⏫Survival 🐭CLP

#FrontImmunol 2025
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Frontiers | Integrated UPLC-ESI-MS/MS, network pharmacology, and transcriptomics to reveal the material basis and mechanism of Schisandra chinensis Fruit Mixture against diabetic nephropathy

Integrated UPLC-ESI-MS/MS, network pharmacology, and transcriptomics to reveal the material basis and mechanism of Schisandra chinensis Fruit Mixture against diabetic nephropathy #FrontImmunol www.frontiersin.org/journals/imm...

Frontiers | Analysis of fatty acid-derived lipids in critically ill patients after cardiac surgery yields novel pathophysiologically relevant mediators with possible relevance for systemic inflammator... IntroductionCritically ill patients suffer from a wide variety of clinical events, most of them leading to pro-inflammatory states such as sepsis or simply a...

Analysis of fatty acid-derived lipids in critically ill patients after cardiac surgery yields novel pathophysiologically relevant mediators with possible relevance for systemic inflammatory reactions #FrontImmunol #MassSpec www.frontiersin.org/journals/imm...

#SpatialTranscriptomics #GeoMx @brukerspatial
Human #AbdominalAorticAneurysm
3x Normal
3x CRP-hi AAA
3x CRP-lo AAA

#SmoothMuscleCell NFκB & JNK signals +corr. CRP level

To explore more in raw data?▶️PRJNA1146589 (SRA) ▶️ not found now😅

#FrontImmunol 2024
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Frontiers | Proteomic profiling of peripheral blood mononuclear cells reveals immune dysregulation and metabolic alterations in kidney transplant recipients with COVID-19

Proteomic profiling of peripheral blood mononuclear cells reveals immune dysregulation and metabolic alterations in kidney transplant recipients with COVID-19 #FrontImmunol #MassSpec www.frontiersin.org/journals/imm...

Frontiers | LRMAHpan: a novel tool for multi-allelic HLA presentation prediction using Resnet-based and LSTM-based neural networks

LRMAHpan: a novel tool for multi-allelic HLA presentation prediction using Resnet-based and LSTM-based neural networks #FrontImmunol #MassSpec www.frontiersin.org/journals/imm...