Pasting error in link (many thanks @rflameiro.bsky.social for flagging this up and I've included correct link) to review of Return to Flatland #Fsp3 #DrugDesign #DrugDiscovery #metric #cheminformatics #MedChem #chemsky 🧪
fbdd-lit.blogspot.com/2025/08/retu...

Drawing on the wisdom of Forrest Gump and Dave Allen, I’ve reviewed Churcher, Newbold & Murray (2025) Return to Flatland, Nat Rev Chem 9:140–141 DOI: 10.1038/s41570-025-00688-5 #Fsp3 #DrugDesign #DrugDiscovery #metric #cheminformatics #MedChem #chemsky 🧪
fbdd-lit.blogspot.com/2025/08/retu...

A Nobel for property-based drug design? [This post was updated on 04-Aug-2024. I thank Tim Ritchie (see RM2009 | RM2014 ) for bringing  YG2003 (Prediction of Aqueous Solubility o...

For JMC to have published a Nobel Prize nomination, Mr. Worthing, may be regarded as a misfortune; to have published a Nobel Prize nomination as an editorial looks like carelessness (re-post) #DrugDesign #metrics #Ro5 #LipE #Fsp3 #MedChem #cheminformatics 🧪
fbdd-lit.blogspot.com/2024/07/a-no...

A Nobel for property-based drug design? [This post was updated on 04-Aug-2024. I thank Tim Ritchie (see RM2009 | RM2014 ) for bringing  YG2003 (Prediction of Aqueous Solubility o...

For a journal to have published a Nobel Prize nomination, Mr. Worthing, may be regarded as a misfortune; to have published a Nobel Prize nomination as an editorial looks like carelessness (re-post) #DrugDesign #metrics #Ro5 #LipE #LLE #Fsp3 #MedChem #chemsky 🧪
fbdd-lit.blogspot.com/2024/07/a-no...

Property-Based Drug Design Merits a Nobel Prize

A distinct lack of #NobelPredictions this year so here's a hot tip from J Med Chem: Christopher Lipinski #Ro5 Paul Leeson #LipE and Frank Lovering #Fsp3 for Physiology/Medicine #MedChem #cheminformatics #chemsky 🧪
doi.org/10.1021/acs....

A Nobel for property-based drug design? [This post was updated on 04-Aug-2024. I thank Tim Ritchie (see RM2009 | RM2014 ) for bringing  YG2003 (Prediction of Aqueous Solubility o...

Re-posting review of JMC Editorial (Property-Based #DrugDesign Merits a Nobel Prize) DOI: 10.1021/acs.jmedchem.4c01345 (please read article before my review) #DrugDiscovery #MedChem #PhysChem #cheminformatics #Ro5 #LipE #LLE #Fsp3 #logP #logD #metrics #chemsky 🧪
fbdd-lit.blogspot.com/2024/07/a-no...

Prediction of Aqueous Solubility of Organic Compounds by Topological Descriptors Two quantitative models for the prediction of aqueous solubility of 1293 organic compounds were generated by a Multilinear Regression (MLR) analysis, and a Backpropagation (BPG) neural network. The m....

#Fsp3: The Descriptor Formerly Known As I_ALI #cheminformatics #MedChem #DrugDesign #DrugDiscovery #chemsky 🧪
doi.org/10.1002/qsar...

I have since learned that #Fsp3 (as i_ali) had actually been used as a descriptor for modelling aqueous solubility 6 years before the publication of the 'Flatland' article and the blog post has been updated to account for this #MedChem #cheminformatics #DrugDesign #metrics #chemsky 🧪

A Nobel for property-based drug design? "The problems of ADME are precisely those that determine success or failure of a drug in vivo. In vitro data can give a clearer picture of t...

I’ve reviewed a JMC Editorial (Property-Based #DrugDesign Merits a #Nobel Prize) DOI: 10.1021/acs.jmedchem.4c01345 & best to read article before reading my review #DrugDiscovery #MedChem #PhysChem #cheminformatics #Ro5 #LipE #LLE #Fsp3 #chemsky 🧪
fbdd-lit.blogspot.com/2024/07/a-no...

Property-Based Drug Design Merits a Nobel Prize

It’s better that people ask why you didn’t win a #Nobel Prize than why you did (usually attributed to Jocelyn Bell Burnell) #MedChem #cheminformatics #DrugDesign #DrugDiscovery #Ro5 #LipE #Fsp3 #chemsky 🧪
doi.org/10.1021/acs....

Property-Based Drug Design Merits a Nobel Prize

Control of physicochemical properties is undeniably integral to contemporary #DrugDesign but I don’t consider property-based design Nobel-worthy (also who would it be awarded to?) #MedChem #PhysChem #metrics #Ro5 #LLE #LipE #Fsp3 #PFI #DrugDiscovery #chemsky 🧪
doi.org/10.1021/acs....

#Reviewer3 expresses a key opinion on the #Fsp3 #metric #MedChem #cheminformatics #DrugDesign #chemsky 🧪 #DrugDiscovery