This study builds a bedside #nomogram including NOAF, age, NYHA class, sodium, platelets, and #GDMT to predict post-CRT mortality in #HFrEF, showing high accuracy & enabling personalized risk stratification, follow-up, & therapy optimization to improve outcomes.
#OpenAccess: tinyurl.com/2c6u2rk2
In HFrEF, optimal sacubitril/valsartan dosing may not always mean max dosing. Real-world studies show comparable outcomes at lower–intermediate doses, highlighting the gap between trials and practice. 📄 :https://rdcu.be/eRbzu #GDMT #JGIM #CHF
How is your team addressing chronic disease education? Share your strategies! 👇
8/7
#MoreThanAJournal #howwehospitalist #HeartFailure #PatientEducation #HospitalMedicine #GDMT #HFpEF #HFrEF #MedTwitter
This #CVIA study evaluating whether #Malnutrition might be associated with under-utilization of #GDMT at discharge among hospitalized patients with #HeartFailure and LVEF <50%, identified crucial gaps that must be addressed to support GDMT implementation.
#OpenAccess: tinyurl.com/2yyhcf7e
At the forefront of cardiovascular innovation.
Updates in Heart Failure 2025 by the Karolinska Institute brings 40+ global experts.
📍 Stockholm & Online
📅 15–16 Dec 2025
🔗 Free registration: heartfailurecongress.tmacademy.org/register/
#HeartFailure #GDMT #Cardiology #Karolinska #UpdatesinHF2025
When to downtitrate/stop #GDMT in #HFrEF? Prof #BiykemBozkurt 🫀
📍Recovered: individualized, may consider de-escalation
📍Improving: continue/optimize
📍Persistent: escalate, close FU/referral
📍Refractory: ⬇️doses/advanced tx
⚠️No solid data for routine withdrawal
#ESCCongress @escardio.bsky.social
In Norway🇳🇴, 4 years after DAPA-HF, 85% of those with reduced ejection fraction heart failure get an SGLT2i. In the US🇺🇸, it's under 30%. #gdmt #flozins #cardiosky
www.hcplive.com/view/study-h...
onlinelibrary.wiley.com/doi/10.1002/...
#NUDGECKD #ERA25 LBT #KristofferSkaar & #TorBiering
SimPub #Circulation
Pragmatic 2x2 factorial #implementation RCT
Randomization at cluster + individual level
E-letters re #GDMT to 1540 GPs & 22617 patients w #CKD did not ⬆️ uptake of #RASi or #SGLT2i
www.ahajournals.org/doi/10.1161/...
【診断後早期のGDMT開始 [可能例】でHFrEFの転帰改善/ ESC HF
デンマークHFレジストリ、HFrEF 46,816例観察：
・診断４週間以内のガイドライン推奨薬「3~4」剤「開始」で「非開
始」に比べ、１年間死亡の補正後HRは0.65 [95CI：0.55-0.78]、３
年間なら0.67 [0.59-0.76]。
・一方、「1~2」剤開始でも0.73 [95%CI：0.61-0.86]と0.75 [0.66-
0.86]。
・CV死亡も同様。
x.gd/OA954
#HFrEF #GDMT
【東アジア人におけるHF標準４剤治療実施率と阻害要因は？/ Int J Cardiol】
中国、AFH入院263例解析：
・退院時、GL推奨４剤治療は55.2%。４剤最大用量服用は7.2%。
・退院後180日までの「HF増悪[含・死亡]」時で検討しても、58.3%
と13.4%。
・４剤治療不耐の主な要因は「腎機能低下」と「低血圧」。
x.gd/e1iSe
#HF #GDMT
New study in #JACCHF on growth hormone (GH) replacement in patients with GH deficiency + #HFrEF
🔸 Improved exercise capacity + #QoL in GH replacement vs controls
🔸 Impetus here to screen for GH more, consider in those with residual symptoms despite #GDMT
📎: www.jacc.org/doi/10.1016/... #CardioSky
#Nudges are behavioral interventions that influence decisions without restricting choices or giving incentives
This 2x2 factorial #RCT will evaluate effect of 🇩🇰 nationwide electronic letter nudges delivered to people with #CKD, their GPs, or both on #GDMT
www.sciencedirect.com/science/arti...
Awesome talk from @mkittlesonmd.bsky.social on #HF in women from #GDMT to #VAD and #transplant #HFpEF #HFrEF
@womensheart.bsky.social
#CardioSky
Efficacy, Safety and Mechanistic Impact of a #HeartFailure Guideline-Directed Medical Therapy Clinic
#JACCHF #CardioSky #GDMT
www.jacc.org/doi/full/10....
@jimjanuzzi.bsky.social @jaccjournals.bsky.social @drmarthagulati.bsky.social @cardioobdoc.bsky.social @shelleyzieroth.bsky.social
🐇 Rapid #GDMT in HF with EF<50% (about 15 weeks) #medsky
Implementation= effective, safe, and associated with HF improvement
💊ARNi 52% vs 8%
💊Beta-blockers 78% vs 6.2%
💊MRA 98% vs 15.6%
💊#flozins 92% vs 6.2%
www.jacc.org/doi/full/10....
How wrong is it that a young adult with a heart function like this is managed in the ambulatory setting with… drumroll… digoxin monotherapy!?!
Yes, really.
#GDMT saves hearts, kidneys, & lives. Only when prescribed.
#HeartFailure
Our new study highlights power of checklists in ACS Care;
✅ Checklist use →
📍 >10% ↑ in #GDMT prescription (p<0.0001)
📍>2x ↑ in early invasive approach (51% vs. 20.7%, p<0.0001)
📍 ↓ 90-day composite outcome (HR 0.61, p=0.0006)
Especially effective in high CCI patients (HR 0.53–0.60)
Guideline-Directed Medical Therapy #GDMT & Outcomes in #ISCHEMIA Trial
#CardioSky #JACC
www.jacc.org/doi/10.1016/...
@michaeldshapiro.bsky.social @jaccjournals.bsky.social @vietheartpa.bsky.social @erinmichos.bsky.social @load-dependent.bsky.social @drmonalidesai.bsky.social @rblument1.bsky.social
Direct-to-Physician Marketing and Uptake of OMT for #HFrEF
📌60% of general & 50% of #AHF cardiologists received ARNI/#SGLT2i marketing (2019-2021)
📌#ARNI meals in 2020 led to +43% to +109% higher prescribing in 2021 for general cardiologist
#HeartFailure #GDMT
www.jacc.org/doi/10.1016/...
How to handle #polypharmacy in heart failure. A clinical consensus statement of the #HFA of the
@escardio.bsky.social @cardioobdoc.bsky.social @drmarthagulati.bsky.social @erinmichos.bsky.social @thanhneville.medsky.social @mmamas1973.bsky.social
#CardioSky #EJHF #GDMT #CardioEd
Thrilled to announce that we have received ~2mill EUR from @helse_og_omsorg to conduct the STRONG@HOME trial at 7 sites in 🇳🇴🎉.
Building on #STRONGHF, this trial will test efficacy and safety of rapid uptitration of #GDMT after HF hosp can be performed by digital follow-up 📲
'that a broader application of #M-TEER in addition to optimal guideline directed medical therapy #GDMT should be considered among patients with symptomatic HF and moderate to severe FMR'
#TEER #mitraclip #MR #chf #cardiosky mitral regurgitation #hfref #hfpef #ic
www.jacc.org/doi/10.1016/...
repost: your #chf patient is on #GDMT and develops hyperkalemia. these 2 meds can help.
#arbs #arni #MRAs Lokelma #SZC #RAASi #cardiosky #cvprev
link.springer.com/article/10.1...
reposting: Higher #GDMT score at discharge was associated with lower mortality, lower mortality or hospitalization, more home time, and lower cost.
#chf #cardiosky #arbs #arni #mra #betablocker #sglt2i
jamanetwork.com/journals/jam...
Analysis of 1078 pts in #STRONG_HF:
📍Rapid #GDMT uptitration (~80% dose by day 90) is safe, feasible & ⬇️#HF readmissions/mortality in pts w/wo #AFib
📍#AFib shouldn’t be a barrier, all #HF pts deserve optimal care #GDMTworks
🔗 www.jacc.org/doi/full/10....
#JACCHF #Epeeps
@jaccjournals.bsky.social
if obese with heart failure and on #GDMT with #sglt2i, it seems to be safe to take #glp1-ra like #semaglutide or #tirzepatide
#cvprev #cardiosky
www.ahajournals.org/doi/10.1161/...
preventing hyperkalemia with #GDMT MRA, potassium binders (nonsteroidal mra's may help too)
#cardiosky #cvprev
link.springer.com/article/10.1...
Why should your team complete the OMT-HF Certificate Program?
▶️ Improve your understanding of evidence-based therapies for HF
▶️ Help your patients achieve better patient outcomes.
▶️ Receive 3.0 credits of CME, CNE (NCPD) and CPE
Get started today: hfsa.org/omt-hf
#OMTHF #GDMT
What do you think? Friend or foe?
This is a combination of outpatient remote monitoring and #Ai decisional algorithm to allow rapid uptitration of Guideline Directed Medical Therapy #GDMT in heart failure therapy. I’ll let you be the judge. #DrBMedicalAi
www.jacc.org/doi/10.1016/...
