Advertisement · 728 × 90
#
Hashtag
#GPR15
Advertisement · 728 × 90
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
1 month ago
Post image

GPR15 shapes how cigarette smoke exposure differentially impacts Crohn’s disease and ulcerative colitis, revealing disease-specific immune pathways.
doi.org/10.1038/s413...
#CrohnsDisease #UlcerativeColitis #GPR15 #MucosalImmunity #EnvironmentalExposure

0 0 0 0
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
3 months ago
Post image

Researchers reveal how #CigaretteSmoke drives opposite outcomes in #IBD by inducing GPR15+ T cells, where #GPR15 amplifies pro-inflammatory Th17 responses to worsen #CrohnsDisease but enhances Treg accumulation to mitigate #UlcerativeColitis.

#CoverPage #STTT: doi.org/10.1038/s413...

1 0 0 0
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
6 months ago
Post image

#CigaretteSmoke modulates #InflammatoryBowelDisease via #GPR15, promoting Th17 responses in TNBS-induced colitis & Treg differentiation in DSS-induced #colitis, highlighting #GPR15 as a potential target for subtype-specific therapies.

#STTT #OpenAccess: doi.org/10.1038/s413...

0 0 0 0