Mucosal immune responses are central to host defense, disease prevention, and treatment, linking barrier immunity with systemic inflammatory control.
doi.org/10.1038/s413...
#MucosalImmunity #HostDefense #ImmuneHomeostasis #DiseasePrevention

GPR15 shapes how cigarette smoke exposure differentially impacts Crohn’s disease and ulcerative colitis, revealing disease-specific immune pathways.
doi.org/10.1038/s413...
#CrohnsDisease #UlcerativeColitis #GPR15 #MucosalImmunity #EnvironmentalExposure

Gut microbiota have multifaceted effects on the immune system of the intestinal mucosa strengthening barrier defense, modulating inflammation and guiding immune tolerance. 🦠
Join us at GMC 2026|Boston |June 15–16
🔗 microbiomecongress.org
#Microbiome #Immunity #GMC2026 #MucosalImmunity #GutMicrobiota

I am excited to share that our latest work is now available as a preprint on BioRxiv.
In this study, we describe and characterize a Pglyrp1-Cre mouse model and uncover previously unappreciated heterogeneity among Pglyrp1-expressing cells across mucosal lymphoid tissues.
#MucosalImmunity #MouseModels

Intranasal circRNA vaccination triggers strong T cell responses against lung cancer—highlighting a needle-free path for future immunotherapies.
#circRNA #LungCancer #TCellResponse #CancerVaccine #MucosalImmunity
www.nature.com/articles/s41...

Induction & Maintenance of Mucosal IgA Responses :
- #Mucosalimmunity is primarily➡️ secretory IgA (sIgA) & tissue-resident memory T (TRM) cells. sIgA neutralizes viral particles at the site of infection through immune exclusion, antigen excretion, & intracellular neutralization.

#Medsky🧪 #IDsky #immunosky #publichealth Challenges & Considerations for Long-Term #MucosalImmunity from mucosal viral infections elicit long-lived IgA responses through type 1 follicular helper T cells, particularly in the context of #COVID19vaccination

#Medsky🧪 #IDsky #immunosky #pedsky #mucosalimmunity #virosky #publichealth Mucosal viral infections elicit long-lived IgA responses through mechanisms that critically depend on type 1 follicular helper T (Tfh1) cells, with site-specific requirements for B cell MHC class II & IFNγ signaling.

Studies indicate that IgA subtype dynamics differ between the upper (nasal) and lower (sputum) respiratory tracts, highlighting the complexity of #mucosalimmunity
pmc.ncbi.nlm.nih.gov/articles/PMC...

#Medsky🧪 #IDsky #virosky #immunosky #mucosalimmunity #publicheath Recent studies on mucosal #COVID vaccines have shown that they induce rapid, but often transient, IgA responses in respiratory secretions,

Researchers highlight the vital role of #MucosalImmunity, detailing its #lymphoid structures, regulatory mechanisms, and emerging therapies, including #MucosalVaccines and inhalable antibodies. #SARSCoV2 #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

Intranasal vaccine combining adenovirus and trimeric subunit protein provides superior immunity against SARS-CoV-2 Omicron variant - Nature Biomedical Engineering A combination of adenovirus-vectored and subunit protein intranasal vaccine enhances immune response against SARS-CoV-2 variants in animal models and humans.

On one side: scientists engineering a nasal COVID vaccine that blocks Omicron transmission and boosts mucosal immunity

On the other: people still yelling “just a cold.”

Follow for science > vibes

#COVID19 #MucosalImmunity #VaccinesWork #PublicHealth #NextGenVaccines #MedSky

University of Houston Researchers Create New Treatment and Vaccine for Flu and Various Coronaviruses Two new nasal sprays to fight coronavirus and flu developed @UHouston: one, a vaccine and one an immune activator.

NanoSTING‑SN: Houston’s intranasal pan‑coronavirus vaccine aims for sterilizing immunity + no transmission.
Strong animal data. Human trials pending funding.
This could be the endgame for COVID spread.
🔗 www.uh.edu/news-events/...
#NextGenVaccines #MucosalImmunity

This review focuses on the multifaceted dimensions of #MucosalImmunity, highlighting its pivotal roles in countering mucosal-related diseases & conditions and underscoring its importance in the development of novel therapeutic approaches. #SARSCoV2 #medsky

Read in #STTT #OpenAccess: buff.ly/cDI6LaK

#Medsky🧪 #IDsky #immunosky #oncosky #publichealth #Immunoglobulin (Ig) A antibodies are involved in #mucosalimmunity and eliminate pathogens immediately at the point of entry.

These findings highlight the potential role of boosters or alternative strategies to sustain #mucosalimmunity in Cancer patients with on going Cancer therapy . cancer patients who received dual-dose BNT162b2 vaccination

Don’t miss Dr. Ana Caetano Faria at SMI's 2025 Principles of Mucosal Immunology Virtual Course as she presents “Oral tolerance: past and present insights.” 🧬

Join 250+ immunologists already registered!

www.socmucimm.org/meetings-eve...

#Immunology #MucosalImmunity #SMICourse2025

Viruses and neurodegeneration: a growing concern - Journal of Translational Medicine Neurodegenerative diseases (NDDs) cause a progressive loss of neurons. Since NDDs are multifactorial, the precise etiology varies on the basis of the type of disease and patient history. Cohort studie...

#mucosalimmunity
link.springer.com/article/10.1...

www.mdpi.com/2218-273X/15...

onlinelibrary.wiley.com/doi/full/10....

pmc.ncbi.nlm.nih.gov/articles/PMC...

papers.ssrn.com/sol3/papers....

Last week, our lab was invited to talk at @keystonesymposia.bsky.social, where we talked about FMT & IBD and investigations on triggers towards healing. #gutmicrobiome #mucosalimmunity #fmt #ibd We would like to thank the organizers for a great meeting. Speaker: @patrickschimmel.bsky.social

#MedSky🧪#IDSky #Mucosalimmunity #publichealth this systematic review shows that the composition of the intestinal #microbiota can impact responses to oral & parental vaccines, affecting bothhumoral & cellular responses. Despite some variability in results amongstudies,

Abstract

#MedSky🧪 #IDSky #Academicsky #Clinicalresearch #publichealth #Mucosalimmunity Beyong #Gutbrainaxis Intestinal epithelial barrier-integrity is essential for human health, and its disruption induces and exacerbates intestinal inflammatory disorders.

Why COVID-19 Vaccines Don’t Stop Transmission This Medial News article discusses recent research showing that current COVID-19 vaccines fail to elicit enough of a mucosal immune response to prevent infection.

don’t elicit adequate #mucosalimmunity in the nose & mouth #SARSCoV2 ’s entry points into the body. Once 🦠 slips past those entry points, systemic immunity generated by #COVID19 💉 & previous infections protects against severe disease. @jama.com

jamanetwork.com/journals/jam...

Needle-Free: New Nano-Vaccine Effective Against All COVID-19 Variants A new nano-vaccine developed by TAU and the University of Lisbon offers a needle-free, room-temperature-storable solution against COVID-19, targeting all key variants effectively. Professor Ronit Satc...

Looking for the part that says in humans instead of in mice. But seeing "mucosal Immunity" was particularly gratifying. scitechdaily.com/needle-free-...
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/pdf/10.1...
#mice #human #vaccine #COVID-19 #intranasal #mucosalImmunity

Hello Bluesky!
We are very pleased to join you all here and are looking forward to a fun and inspirational time 😃
We are interested in immunology, specifically in the upper airway #ENT #ImmunoSky #MedSky #Mucosalimmunity #AcademicSky

Have a productive day everyone 🤗

Viral infection and antiviral immunity in the oral cavity - Nature Reviews Immunology The oral mucosa is a critical barrier tissue that is continually exposed to pathogens, but antiviral immune responses in this tissue are poorly understood. Moreover, recent viral outbreaks, including ...

#MedSky🧪 #IDsky #Immunosky #Mucosalimmunity overview of antiviral immune responses in the oral cavity in common viral infections & their manifestations in the oral mucosa.

www.nature.com/articles/s41...

Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection ameliorates secondary influenza A virus disease Pathogen encounter can result in epigenetic remodeling that shapes disease caused by heterologous pathogens. Here, we examined innate immune memory in…

#MedSky🧪 #IDsky #PedSky #ImmunoSky #Mucosalimmunity #Antiviral #innateimmune memory in alveolar #macrophages following #SARSCoV2 infection ameliorates secondary influenza A virus disease

www.sciencedirect.com/science/arti...

Sublingual Immune cell cluster (SLIC)

#MedSky🧪 #IDSky #ImmunoSky #Mucosalimmunity Overview Sublingual immune cell clusters and #dendriticcell distribution in the oral cavity

insight.jci.org/articles/vie...

#MedSky🧪 #IDSky #Immunosky #Publichealth #Publichealth #Mucosalimmunity #Autoantibodies targeting interferon-α (#IFNα) have been found in the circulation of those with severe #COVID19 and are considered a bad sign for disease progression.

#MedSky🧪#IDSky #Immunosky #Pulichealth There is reason why you are still wearing 😷 when you had already vaccinated . Ideally, #COVID19vaccines protect against not only severe #COVID but also infection to limit 🦠 circulation. Achieving this goal requires the induction of #mucosalimmunity through 💉

Microbial hoolIgAn dismantles gut defenses Immunoglobulin degradation by a gut bacterium causes immunodeficiency in mice

#MedSky🧪#IDSky #Microbiology This study provides evidence regarding the critical role played by the degradative capabilities of the #gutmicrobiome in specific aspects of the #mucosalimmunity and intestinal barrier system.

www.science.org/doi/10.1126/...