This is the first formal analysis of the field. So please share it widely - hope this is a tool of wide use to the #genedrive community.

And more exciting work on what we do and don't know about making functional #genedrive is about to drop!

Habtewold et al. (2026) share exciting results on using gene-drive mosquitoes to fight malaria in Tanzania! Locally adapted tech shows promise!. #Malaria #GeneDrive #Science #Tanzania

Check out the video!

youtu.be/YfjhpKWSIO4

Transmission Zero scientists achieve landmark breakthrough in the fight against malaria in Tanzania Our new study published in Nature marks a milestone for African-led innovation, as our researchers develop genetically modified mosquitoes capable of blocking malaria transmission in Tanzania.

In our latest blog, we unpack our new Nature paper, where our team have developed a strain of mosquito in Tanzania that can block malaria transmission - the first genetically modified mosquito ever to be created in Africa, by African researchers.

Read here: bit.ly/4p72aMF

#malaria #genedrive

Gene-drive-capable mosquitoes suppress patient-derived malaria in Tanzania - Nature Engineering of local Anopheles gambiae under containment enables the generation of a transgenic strain equipped with non-autonomous gene drive capabilities that robustly inhibits genetically diverse P...

A step closer towards the application of new genetic technologies to interrupt #malaria transmission, the study reports successful generation of genetically modified mosquitoes, creating a barrier against malaria transmission ➡️ www.nature.com/articles/s41... #genedrive #geneticengineering

While we are working on an oral contraceptive for grey squirrels, the @roslininstitute.bsky.social & European Squirrel Initiative are looking into #genedrive technology. This Confor article from a few years ago provides a useful overview: www.confor.org.uk/media/267820... #genetics #wildlife

Imperial-led project brings gene-drive mosquitoes closer to reality in Africa An Imperial-led project has made a major advancement in developing gene drive modified mosquitoes to eliminate malaria transmission in Africa.

Want to know more about today’s Nature paper? 💡

Transmission Zero scientists have generated the first transgenic mosquitoes in Africa and shown that they’re effective in resisting malaria parasite infection.

Read the Imperial News Story here: bit.ly/3YhB8r4

#genedrive #malaria

Rewriting the Planet: The De-Extinction Gamble 🧠 Tech Takedown

We can bring back the #Mammoth. But should we? 🦣🧬 We expose #Colossal's de-extinction gamble & the #GeneDrive tech that can wipe out entire species. From "#Hitler Pig" nightmares to climate crops, are we saving nature or breaking it?

🎧 LISTEN NOW 👇
open.spotify.com/episode/29Qu...

A close up of an Anopheles gambiae mosquito on a person’s finger. Image credit: Science Source/CDC/James Gathany

Opinion piece: Here’s how to reduce the chances of gene drives causing collateral damage. In PNAS Front Matter: https://ow.ly/2oEl50XuOGg

#GeneDrive #TargetSpeciesComplex #RiskAssessment #PublicHealth #agriculture #malaria #mosquitoes #vector #AnophelesGambiae

A close up of an Anopheles gambiae mosquito on a person’s finger. Image credit: Science Source/CDC/James Gathany

Opinion piece: How to greatly reduce the risk of gene drives causing collateral damage. In PNAS Front Matter: https://ow.ly/yszs50XsR5p

#GeneDrive #TargetSpeciesComplex #RiskAssessment #PublicHealth #agriculture #malaria #mosquitoes #vector #AnophelesGambiae

Out-of-the-Box Innovations Against Malaria How genetically modified mosquitoes and other strategies could dramatically reduce malaria transmission.

Listen to Transmission Zero's Dickson Lwetoijera and Nikolai Windbichler on Foreign Policy's new podcast: The Threshold!

Hear why innovation in malaria control is so urgent, and how we are working on new approaches to stop mosquitoes spreading disease here: bit.ly/3WLcONH

#GeneDrive #Malaria

A close up of an Anopheles gambiae mosquito on a person’s finger. Image credit: Science Source/CDC/James Gathany.

Opinion piece: How gene drives and species complexes pose real risks of collateral damage. In PNAS Front Matter: https://ow.ly/UPH750XnNxh

#GeneDrive #TargetSpeciesComplex #RiskAssessment #PublicHealth #agriculture #malaria #mosquitoes #vector #AnophelesGambiae

After ‘humiliating’ raid, Burkina Faso halts ‘gene drive’ project to fight malaria Disinformation campaign may have triggered “brutal” shutdown of mosquito lab

After ‘humiliating’ raid, #BurkinaFaso suspends #malaria #genedrive project.
Mosquito lab faces abrupt shutdown amid #disinformation campaign.

www.science.org/content/arti...

After ‘humiliating’ raid, Burkina Faso halts ‘gene drive’ project to fight malaria Disinformation campaign may have triggered “brutal” shutdown of mosquito lab

#malaria
#genedrive
#BurkinaFaso
#misinformation

"But opposition to the project has grown, fueled in part by false accusations spread through social media, such as that Target Malaria was weaponizing mosquitoes to spread disease or sterilize people."

Multiplexing gene drives have high homing efficiencies

Excited to be a part of this new paper with Alphey Lab- out in pre-print.
Multiplexing overrides resistance for #genedrive in Anopheles stephensi
www.biorxiv.org/content/10.1...

Alleles that have mismatches compared to designed homology arms produce a significant drop in homing events while overall cleavage rates remain the same

🚨New pre-print🚨
Natural DNA variation can slash CRISPR gene drive efficiency by up to 54% in Culex quinquefasciatus, a major West Nile virus mosquito vector.
<10% mismatch at the target site disrupts copying.
#GeneDrive #CRISPR
(with Tim Harvey-Samuel and Alphey Lab)
doi.org/10.1101/2025...

Drs @mlwilde.bsky.social Sarah Farrell, Christopher Goodman & @fad1.bsky.social review novel techniques for disrupting #malaria #transmission. #Plasmodium #Mosquito #GeneDrive #Paratransgenesis

authors.elsevier.com/a/1lPdi_XTJP...

On the question of gene drives, “Africa will have the ultimate say” - but do people know they are being asked? A promising technology could save thousands of lives from malaria, but its rollout is controversial. How can public communication strategies reach the people of Uganda, who may soon find themselves at...

Well worth reading!! @springernature.com #Bugbitten blog by Dr Timothy Little on how #SciComm strategies can support the public debate on #Genedrive technology for infectious disease control in #Uganda.
I wonder if SciComm strategies can leverage #citizenscience approaches?

go.nature.com/3Zf3Rhb

Quali specie nocive abbiamo il diritto di estinguere? I ricercatori hanno analizzato tre casi esemplari in cui si potrebbe ricorrere all’estinzione deliberata attraverso i cosiddetti gene drive: mosche assassine, zanzare della malaria e ratti invasivi

www.lescienze.it/news/2025/05... #genedrive

Bill Gates talking about #genedrive as one of the tools in the pipeline that could help end #malaria in the next 20 years @transmission-zero.bsky.social @targetmalaria.org

Tomorrow, hear from T0's George Christophides at the Johns Hopkins Malaria Research Institute’s World Malaria Day Symposium, “Building Better Mosquitoes”!

If you’re at the symposium, we hope you can join us!

#WorldMalariaDay2025 #GeneDrive #Malaria
@gkchris.bsky.social @jhmrimalaria.bsky.social

If we have to make #malaria a thing of the past for future generations, let’s reimagine the fight against this disease by leveraging cutting-edge research such as #GeneDrive. #WorldMalariaDay
@genedrivenet.bsky.social

Optimization of SgRNA expression with RNA pol III regulatory elements in Anopheles stephensi - Scientific Reports Scientific Reports - Optimization of SgRNA expression with RNA pol III regulatory elements in Anopheles stephensi

Check out our new study in An. stephensi:
Variable gene drive efficiency across 4 Pol III promoters (but up to 99.8%) - building essential knowledge for next-gen drives. Key challenges remain - maternal Cas9 causes high rates of early somatic editing. #genedrive www.nature.com/articles/s41...

The 2nd Women in Malaria Conference: A platform for change - Gene Drive Network Last week, the 2nd Women in Malaria (WiM) Conference convened women and non-binary researchers for a two-day virtual event highlighting their contributions to the fight against malaria.

Hear from Transmission Zero and Ifakara Health Institute's Felista Tarimo on the 2nd Women in Malaria conference held last week. An excellent opportunity for researchers to connect and showcase their work!

🔗 Find the Outreach Network blog here: bit.ly/4c6C0Vw

#WiM2025 #EndMalaria #GeneDrive

Gene drive evidence placement | Harry Marshall 3-month PhD student #placement opportunity to review the #evidence for the use of gene drive as a tool for the eradication of invasive non-native species…

3-month PhD student #placement opportunity to review the #evidence for the use of #genedrive as a tool for the eradication of invasive non-native species. Ideally based in #Cambridge to maximise the students's in-person interactions but other locations considered.

www.linkedin.com/posts/harryh...

Target Malaria: The Game! Beta launch ready for download - Target Malaria Welcome to Target Malaria: The Game! A video game experience that will immerse you in the role of a Target Malaria lab researcher developing genetically modified mosquitoes to fight malaria in Africa....

Target Malaria: The Game is here to bring science to your screen!

Explore how innovative tools like #GeneDrive can help fight against deadly #Malaria 🦟

Download the beta now & let us know your highest score using the hashtag #TargetMalariaTheGame:
targetmalaria.org/latest/news/...

#EndMalaria

New strategies for pest insect control by population suppression | Doctoral Training Partnership CHAPMAN_U25DTP1

Probably don't have the reach on here yet - BUT:
I have a fully-funded four year PhD studentship available - the deadline is soon - November 25th - so please share if you can.
And let's connect if you are interested in #genedrive #pestcontrol #evobio
biodtp.norwichresearchpark.ac.uk/projects/new...

I am going to try and get back into posting a bit more regularly. Probably like most people twitter left me a bit bruised and jaded...
Anyway I am interested in #highered #rstats #genedrive #biology if you are too let's connect!

Using genomics to find solutions to malaria Across Africa, researchers are looking at the use of new technologies to curb the spread of malaria, but there are many challenges

🦟"Using genomics to find solutions to #malaria:
Across #Africa 🌍, researchers are looking at the use of new technologies to curb the spread of malaria, but there are many challenges." #Anopheles #SIT #GeneDrive #CRISPR
www.nature.com/articles/d44...

Gene drive mosquitoes for malaria control: complexities of governance | LSHTM Gene drive mosquitoes is a short documentary film that is beautifully shot in Uganda and explores Ugandan stakeholders’ hopes for gene drive mosquitoes. Uganda, where malaria is the main cause of deat...

For anyone doing #sts or #globalhealth and mooching around in London tomorrow, we have this event on #genedrive mosquitoes and #malaria happening at LSHTM 🦟

www.lshtm.ac.uk/newsevents/e...