Epigenetics Update - Transient histone deacetylase inhibition induces cellular memory of gene expression and 3D genome folding go.nature.com/4ae5JeL

#Epigenetics #Chromatin #GenomeFolding
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High-resolution insights without cell sorting; epigenometech.com

Spontaneously directed loop extrusion in SMC complexes emerges from broken detailed balance and anisotropic DNA search Abstract. DNA loop formation by structural maintenance of chromosome (SMC) proteins, including cohesin, condensin, and the SMC5/6 complex, plays a pivotal

⭐NAR Breakthrough!⭐
Bonato et al. propose a model for how the yeast #condensin SMC complex drives persistent #DNAloopextrusion, using #atomicforcemicroscopy and #moleculardynamics.

Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #SMC #biophysics #genomefolding #yeast