This review explores how #HistoneDeacetylases regulate #VascularHomeostasis via endothelial and smooth muscle cells, highlighting their role in vascular #Pathogenesis and the therapeutic potential of #HDACinhibitors.

#OpenAccess: doi.org/10.1016/j.ge...

Crystal structures of a clinically used histone deacetylase inhibitor, vorinostat, bound to the previously unidentified off-target proteins carbonic anhydrases II and IX are reported #HDACInhibitors #SAHA #Vorinostat doi.org/10.1107/S205...

The Hidden Gene Driving Prostate Cancer’s Dark Turn A single gene may hold the key to why prostate tumors turn aggressive — and scientists now have a way to switch it off using approved drugs.

A newly discovered gene may explain why some prostate cancers become deadly — and how we might stop them. #ProstateCancer #GeneTherapy #HDACinhibitors

Histone deacetylases: Regulation of vascular homeostasis via endothelial cells and vascular smooth muscle cells and the role in vascular pathogenesis

Review article alert!

This review summarizes the regulatory role and mechanisms of #HistoneDeacetylases (HDACs) in the #vascularsystem, describes their recent research developments and addresses the therapeutic effects and prospects of #HDACinhibitors. #medsky

#OpenAccess: buff.ly/rLNzuyV