Structures of two lyssavirus glycoproteins trapped in pre- and post-fusion states and the implications on the spatial-temporal conformational transition along with pH-decrease Author summary Lyssavirus, as represented by the prototypic rabies virus, is responsible for approximately 60,000 human fatalities annually. The glycoprotein of lyssavirus is a key factor mediating th...

Researchers captured MOKV and IKOV glycoproteins in pre- and post-fusion states, revealing pH-induced changes in membrane fusion. This study presents the first solved IKOV structure. journals.plos.org/plospathogen... #virology #Lyssavirus #IKOV #MOKV