Using antigenic cartography & #NAb profiling, this #STTT study shows that prototype-targeting vaccination followed by Delta/early #Omicron infections shifted #ImmuneImprinting from WT dominance toward #XBB adaptation.

#OpenAccess: doi.org/10.1038/s413...

This #STTT study demonstrates that prototype-targeting #Vaccination with Delta/early #Omicron breakthrough maintains wild-type immunity, while #XBB.1.5-adapted vaccination following BA.5 shifts #ImmuneImprinting toward XBB.1.9.1. #medsky

#OpenAccess: doi.org/10.1038/s413...