The anterior‒posterior axis regulatory molecules HOXA13 and CDX2 mediate bile acid-induced gastric intestinal metaplasia through a positive feedback loop Gastric intestinal metaplasia (IM) is an important precancerous lesion, but the mechanisms underlying its development and phenotype maintenance have n…

An FXR-mediated HOXA13–CDX2-positive feedback loop drives the development & phenotypic maintenance of bile acid-induced gastric #IntestinalMetaplasia, establishing a potential #TherapeuticTarget for #GastricCancer prevention.

#OpenAccess: doi.org/10.1016/j.ge...

An FXR-mediated HOXA13–CDX2-positive feedback loop drives the development & phenotypic maintenance of bile acid-induced gastric #IntestinalMetaplasia, establishing a potential #TherapeuticTarget for #GastricCancer prevention.

#OpenAccess: doi.org/10.1016/j.ge...

Margarita teaching us at #DDW2025 how #IntestinalMetaplasia may occur using a new mouse model.