1/2 In this #JEMLegacy, we revisit a study published in 1963 by Dr. Irwin Lepow that identified C1q, C1r and C1s as subcomponents of the C1 complement complex (rupress.org/jem/article/...).
#immune #complement

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. We investigated the antigen specificity and presentation requirements for inactivation of T lymphocytes in vitro and in vivo. In vitro studies revealed tha

This month #JEMLegacy is going back to 1987 when Marc Jenkins and Ronald Schwartz first described that TCR engagement (signal 1) alone induces T cell unresponsiveness and anergy, setting the stage for the understanding of T cell costimulation 🧪 Take a look here 👉 tinyurl.com/4sebepmr

Happy New Year from all of us @jem.org. For this month’s #JEMLegacy we are going back to the 90s with this report on lymphotoxin’s role in chronic inflammation
tinyurl.com/2ua2cezw

SEROLOGICAL REACTIONS IN PNEUMONIA WITH A NON-PROTEIN SOMATIC FRACTION OF PNEUMOCOCCUS 1. Sera from individuals acutely ill with lobar pneumonia possess the capacity to precipitate in high titre a non-protein somatic fraction derived from pne

#JEMLegacy @jem.org goes back to 1930 with the first description by William Tillett and Thomas Francis Jr. of C-reactive protein (CRP) in the sera of patients during the acute phase of pneumococcal pneumonia.

@RockUPress @RockefellerUniv

rupress.org/jem/article/...

Beautiful talk from Sohail Tavazoie at #SITC25! The intersection between neuroscience and cancer is fascinating, and particularly enjoyed the reminder that nerves in cancer were identified in @jem.org in 1897! 🧐 #JEMlegacy rupress.org/jem/article-...

In light of Monday’s #Nobel Prize in Physiology or Medicine announcement, for #JEMLegacy let’s look back at one of Shimon Sakaguchi’s early @jem.org papers from 1985! rupress.org/jem/article/...

This #JEMLegacy tweet highlights two papers from 1965 by Drs. Phil Gold and Samuel O. Freedman @mcgill.ca on the discovery of the Carcinoembryonic Antigen (CEA), the basis for the widely used CEA blood test.
rupress.org/jem/article/...
rupress.org/jem/article/...

#cancer #biomarker #CEA

IMMUNITY TO POLIOMYELITIS IN MOTHERS AND THE NEWBORN AS SHOWN BY THE NEUTRALIZATION TEST Neutralization tests for the virus of poliomyelitis on blood serum of urban mothers and their newborn infants showed that immunity was present in ten out o

Back to school, back-to-back #JEMLegacy with this study of neutralization tests for poliomyelitis in newborn infants and mothers…from 1930! tinyurl.com/59nnnuan

This #JEMLegacy tweet takes you to a 1999 study by Dr. Muriel Moser that demonstrated the functional dichotomy between CD8a+ and CD8a- DCs in driving distinct T helper cell responses.
rupress.org/jem/article/...
#Immunology #DendriticCell #THelperCell

In honor of last week’s #ksneuroimmune25 #ksneurodegen25 meetings, for #JEMLegacy today let’s revisit the birth of the EAE model in 1933! 🧠🧐rupress.org/jem/article/58/1/39/3215...