Fig. 2. An overview of the main mechanisms of antifungal resistance in C. glabrata.
Galleria mellonella as a versatile model for investigating Candida glabrata virulence and antifungal resistance. Published in JMM as part of the Fungal Pathogenesis: Mechanisms, Resistance, and Threats collection: https://doi.org/10.1099/jmm.0.002127
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Streptococcus agalactiae colonization in pregnant women: which culture-based detection method is best? Learn more in JMM: https://doi.org/10.1099/jmm.0.002115 #JMedMicro
Fig. 2. (a) L98-whole patient image bundle-syber green (cycling analysis), (b) L98-whole patient melt analysis image, (c) M220-whole patient image bundle-syber green (cycling analysis) and (d) M220-whole patient melt analysis images.
Investigation of azole resistance in Aspergillus species isolated from clinical specimens by azole agar screening method. Available to read in JMM: https://doi.org/10.1099/jmm.0.002112
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Core genome phylogeny of 91 M. plutonius isolates from US apiaries collected between 2019 and 2023. Isolates with blue text published from previous studies were retrieved from NCBI. Isolates used in this study are outlined in red, and phylogeny between study isolates is outlined on the right. DAT561 and S1 represent atypical and typical reference strains, respectively, obtained from NCBI. Numbers and arrows represent bootstrap values.
Potential confounding factors in currently used antibiotic susceptibility assays for the honey bee pathogen Melissococcus plutonius. . Published Open Access and fee-free in JMM using a Publish and Read agreement: doi.org/10.1099/jmm....
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Effect of increasing concentrations of fluconazole on clinical and lab-generated strains of C. glabrata: the figure shows the effect on drug susceptibility of increasing concentration of fluconazole on different strains of C. glabrata.
Mechanism of azole resistance in Candida glabrata isolates from India: clinical vs. induced perspectives. View the full details in JMM: doi.org/10.1099/jmm....
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Verification of the yeast bait plasmid pGBKT7-BspC. 1, pGBKT7-BspC plasmid control; 2, double enzyme digestion of the pGBKT7-BspC plasmid; M, DL10000 DNA marker.
The synergistic pathogenic mechanism of Brucella melitensis M5-90 effector protein BspC in regulating host cell apoptosis, inflammation and oxidative stress. Read now in JMM: doi.org/10.1099/jmm....
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Targeted detection of Helicobacter pylori resistance to clarithromycin and levofloxacin using single-cell Raman spectroscopy. Available to read in JMM: doi.org/10.1099/jmm....
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T. cruzi infection induces morphological changes in cMVEC. cMVEC monolayers were infected at m.o.i. of 1 and 10. (a) As early as 2 h p.i., cells begin to show signs of activation, including cell spreading and elongation. 100×, scale bars=100 µm. (b) Monolayers were fixed at days 1 and 5 p.i. and stained for VE-CAD (Alexa488, green) and nuclei (DAPI, blue). 100× magnification showing the presence of giant cMVEC. Scale bars=100 µm. (c) 400× magnification of giant cMVEC at 5 days p.i. with arrows indicating multiple nuclei, asterisks (*) indicate parasite amastigote nests. Scale bars=20 µm.
Trypanosoma cruzi infection-induced changes in cardiac microvascular endothelial cell morphology and function. Learn more in JMM: doi.org/10.1099/jmm.... #JMedMicro
Microbial levels in peri-implant health and disease. Bar plots showing the quantitative levels of key microbial species in peri-implant health, mucositis and peri-implantitis. Statistical comparisons between groups were conducted using the Mann–Whitney U test. A P-value <0.05 was considered statistically significant.
Quantitative real-time PCR detection of Porphyromonas gingivalis and Filifactor alocis in peri-implantitis. Get the full details in JMM: doi.org/10.1099/jmm.... #JMedMicro
Visual judgement of turbidity in test tubes containing MHB and viable count. The black line is placed in the background of the test tubes, and it becomes less visible when the MHB in the test tube becomes turbid. In this examination, all the microbiologists judged test tubes A and B as turbid. In contrast, all the microbiologists judged test tubes F, G and H as non-turbid (clear).
Limitations of antimicrobial agent choice based on MIC value against Pseudomonas aeruginosa. Available to read in JMM: doi.org/10.1099/jmm.... #JMedMicro
Commercial molecular diagnostic methods in infectious diseases: keeping up with the pathogens. Available to read in JMM as part of the Diagnosis of Infectious Diseases collection: doi.org/10.1099/jmm....
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Design of susceptibility testing method.
Mathematical modelling of synergistic triple-antibiotic therapy against carbapenem-resistant Acinetobacter baumannii at clinically achievable concentrations. Find out more in JMM: doi.org/10.1099/jmm.... #JMedMicro
Image of a group of cupped hands holding the red ribbon in solidarity for AIDS
It's World AIDS Day. Understanding the high mortality rates associated with Talaromyces marneffei in patients with AIDS is vital. Recognising key risk factors can improve prevention and treatment strategies. Read more about this in JMM: doi.org/10.1099/jmm.... #JMedMicro
(a) Comparison of the alpha diversity of gut microbiota among different groups, presented as the Shannon index reflecting species evenness. Statistical significance between the NM group and CIH group was assessed by Student’s t-test (*P<0.05), while differences between the 0-week and 6-week groups were evaluated using paired sample t-test (†P<0.05). (b) Comparison of the beta diversity of gut microbiota among different groups, presented as PCoA based on Bray–Curtis distances. (c) PERMANOVA analysis (◊◊P<0.01, 999 permutations).
Changes in the gut microbiota in mice exposed to chronic intermittent hypoxia. Find out more in JMM: doi.org/10.1099/jmm.... #JMedMicro
Close-up of a 1968 electron microscope image showing a developing Prototheca algae cell with labelled structures N and G.
Side-by-side comparison of Prototheca bovis cell images from 1968 and 2021.
Technological advances, like the improvement of visualisation techniques, have been vital to the advancement of microbiology. Compare these #JMedMicro visualisations of Prototheca species from 1968 and 2021 - doi.org/10.1099/jmm....
Pie charts showing proportions of blood cultures in the no identification compared with the correct identification groups in the baseline and intervention periods.
Hot chocolate: pre-warming chocolate agar improves correct organism identification from choc drop by 16.1%. Published Open Access and fee-free in JMM using a Publish and read agreement: doi.org/10.1099/jmm.... #JMedMicro #PublishAndRead
AMPH-B is the most effective agent in combination with MEPM against E. coli-C. albicans dual-species biofilms. Dual-species biofilms were treated with no antimicrobial drugs, only MEPM (50 µg ml−1) or a combination of MEPM (50 µg ml−1) and antifungals such as FLCZ, AMPH-B or MCFG (10 µg ml−1). The survival of E. coli (a) and C. albicans (b) was quantified by selective plating. Data are presented as means±sd from three replicates.
Combination effect of meropenem and antifungals against Escherichia coli-Candida albicans dual-species biofilms in vitro and in vivo using a silkworm model. Read the full article in JMM: doi.org/10.1099/jmm.... #JMedMicro
Standard population pyramid.
Parasitology of the twenty-first century: are we moving in the right direction? Published Open Access and fee-free in JMM using a Publish and read agreement: doi.org/10.1099/jmm.... #JMedMicro #PublishAndRead
Fig. 1. Biofilm formation of CF pathogens in mono- and co-culture. (a) Crystal violet quantification of biofilm formation of P. aeruginosa and A. xylosoxidans isolates in monoculture. (b) Biofilm formation of P. aeruginosa isolate PsA9 grown in monoculture or together with three pairs of early (AX-1A, AX-3A and AX-5A) and late (AX-1B, AX-3B and AX-5B) A. xylosoxidans isolates. (c) PsA9 was co-cultured with increasing proportions of A. xylosoxidans AX-3A, followed by quantification of biofilm formation. Each dot in the graphs represents the average value of 3 replicates, and bars represent the mean. *P<0.05, **P<0.01.
The cystic fibrosis pathogen Achromobacter xylosoxidans inhibits biofilm formation of Pseudomonas aeruginosa. Published Open Access and fee-free in JMM using a Publish and read agreement: doi.org/10.1099/jmm.... #JMedMicro #PublishAndRead
Fig. 1. Preparation of propolis extract.
The antimicrobial activity of propolis extract on Klebsiella pneumoniae and Escherichia coli strains isolated from Qazvin hospital personnel. Discover more in JMM: doi.org/10.1099/jmm.... #JMedMicro
It's Urology Awareness Month! Explore the link between microbiota and urological cancers in Journal of Medical Microbiology: doi.org/10.1099/jmm.... #UrologyAwarenessMonth #JMedMicro
Graphical Abstract: Schematic overview of COVID-19–associated bacterial co-infections in burn patients. Burn-related skin barrier damage, immunosuppression, and prolonged hospitalization increase susceptibility to pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa during SARS-CoV-2 infection.
The relationship between respiratory tract infections caused by toxin-producing bacteria in burn patients during COVID-19: pathogenesis, diagnostics and novel therapies. Read the full review in JMM: doi.org/10.1099/jmm.... #JMedMicro
The Ebola virus – going beyond the bleeding edge. Published Open Access and fee-free in JMM using a Publish and read agreement: doi.org/10.1099/jmm.... #JMedMicro #PublishAndRead
Only one day left until the #JMedMicro talk with Prof Thuy Do! Don't miss out on their talk ‘Exploring the low-abundant members of the oral microbiome’. Register here:
Fig. 1. Antibacterial activity of C. chinensis and S. officinalis extracts. Gram-negative and Gram-positive bacteria were treated with ethanolic extracts of C. chinensis (a) and S. officinalis (b). MBC was calculated as microgram of non-volatile constituents per millilitre of extract. MBC values of 800 µg ml−1 indicate no antibiotic activity. Error bars denote the standard deviation from three separate experiments.
Topoisomerase inhibitory activity of ethanolic extracts from botanicals Coptis chinensis and Salvia officinalis. Read now in #JMedMicro:
doi.org/10.1099/jmm....
📝Call for papers📝
I'm co-editing a @microbiologysociety.org #JMedMicro collection on Fungal Pathogenesis.
Contribute a review, research or short communication article by Nov 2025 (flexible)
If interested, get in touch!
#FungalPathogens #MedicalMycology #InfectiousDiseases
Join Prof Thuy Do’s #JMedMicro Seminar this Friday on ‘Exploring the low-abundant members of the oral microbiome'. Register here:
Join us at 2pm today for this month’s Journal of Medical Microbiology seminar by Prof Thuy Do on ‘Exploring the low-abundant members of the oral microbiome’. Register here for joining instructions: microb.io/JMMSeminar #JMedMicro
Fig. 1. Isolates submitted per week to the GBRU during phase 1 and phase 2 (7 June–31 August 2021) of the Campylobacter Enhanced Surveillance Programme in England (n=7,778).
Enhanced laboratory surveillance study of Campylobacter species in England. Published #OpenAccess and fee-free in #JMedMicro as part of the JMM Profiles collection using a #PublishAndRead agreement:
doi.org/10.1099/jmm....
Fig. 1. Oral microbial diversity in patients with obesity or obesity with AN. (a–d) Microbial alpha diversity was estimated based on ACE (a), observed species (b), Faith’s PD (c) and Shannon (d) indices in the healthy control (n=50), obesity (n=49) and obesity with AN (Ob_AN, n=50) subgroups. Different lowercase letters indicate significant differences (P<0.05). (e–g) Beta diversity of Bray–Curtis (e), Jaccard (f) and unweighted UniFrac (g) distances in the three groups based on PCoA. Different lowercase letters in a–d indicated significant differences (P<0.05).
Oral microbiota signatures in obesity with or without acanthosis nigricans in a Chinese cohort. Available now in #JMedMicro:
doi.org/10.1099/jmm....
