A new🐭model of peripheral #Atherosclerosis🤠

Partial Femoral Artery Ligation +AAV-PCSK9 +HFD
The lesion is so foamy😁

This ligation procedure
⏫femoral artery Stiffness
⏫Piezo1 expression across Endothelial, Smooth Muscle Cell, Mφ

Piezo1 ⬆️in 🧍‍♂️PAD artery

#JVS_VascSci 2025
jvsvs.org/article/S266...

#PentosePhosphatePathway #SmoothMuscleCell

Inhibiting PhosphoGluconate Dehydrogenase/PGD (with local Hydrogel delivery of Physcion)⏬Neointima formation in injured rat carotid artery

Next, PGD in #Atherosclerosis?😆

Bowen Wang lab #JVS_VascSci 2024
jvsvs.org/article/S266...