NOX4 Suppresses Ferroptosis Through Regulation of the Pentose Phosphate Pathway in Colorectal Cancer

Scientists identify #NOX4 as a key therapeutic target in #ColorectalCancer, showing that its interaction with #G6PD boosts the #PentosePhosphatePathway, enhances #ROS clearance, suppresses #ferroptosis, and promotes #tumor cell survival.
Read: doi.org/10.1007/s115...

A systematic analysis of #Transcriptomic and survival data for NOXs across 22 tumor types reveals that NOX4 suppresses #Ferroptosis by enhancing the #PentosePhosphatePathway, and therefore could serve as a #TherapeuticTarget against #ColorectalCancer. #medsky

Read: link.springer.com/article/10.1...

#PentosePhosphatePathway #SmoothMuscleCell

Inhibiting PhosphoGluconate Dehydrogenase/PGD (with local Hydrogel delivery of Physcion)⏬Neointima formation in injured rat carotid artery

Next, PGD in #Atherosclerosis?😆

Bowen Wang lab #JVS_VascSci 2024
jvsvs.org/article/S266...