🚨 New preprint from the lab!

🧠 Despite representing <5% of total #KCC2 in mature neurons, we show that the KCC2a isoform acts as a powerful developmental switch: inhibiting KCC2b early on, then boosting its membrane expression and fonction in the adult brain.

www.biorxiv.org/content/10.6...

Recent #Research by Jadwiga N. Bilchak of pennmedicine.bsky.social et al. finds that #KCC2 enhancers normalize reflex responses and improve #locomotor function after chronic spinal cord injury 🧠 ⚙️

📜 Read the study here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Potassium–chloride cotransporter 2 activity dampens induced ictal‐like activity in neocortical slices containing the seizure propagation zone of temporal lobe epilepsy patients The K⁺/Cl− cotransporter (KCC2) limits induced ictal-like events and their spread in the supragranular layer of human neocortical slices from the seizure-propagation zone of temporal lobe epilepsy pa...

KCC2 mitigates ictal-like events and their propagation in supragranular layers of neocortical acute brain slices from the seizure propagation zone of TLE patients.
doi.org/10.1111/epi....

#epilepsy #ILAE #Epilepsia #chloridehomeostasis #KCC2 #microelectrodeArray #seizurepropagation

“Neuronal chloride transporters in health and disease” symposium chaired by Xin Tang from Boston Children’s!
Learn more
about #KCC2 regulation: visit Carla Pagan’s poster on unexpected isoform-specific functions on Friday PM session (PS05-28AM-347)
#FENS2024