Original post on mastodon.social

The 23 studies that the #FDA based its expanded #leucovorin label on.

The science supports it for a rare disorder with “autism-like’”symptoms.

The sole paper linking it to autism was retracted in January.

“Leucovorin prescriptions for children with autism increased by 71 percent after a White […]

#FDA update on #leucovorin
It was approved for a rare genetic disorder that impairs folate delivery to the brain not #autism
✔️ Best signal → language improvements
✔️ Some effect → social communication
✔️ Biggest responders → abnormal folate metabolism
Evidence > hype
#mentalhealth #ASD #medication

Leucovorin autism prescriptions surge after White House promotion - WTF WIRE Leucovorin autism prescriptions surge after White House promotion, leaving parents struggling to find the drug at pharmacies.

Leucovorin #autism prescriptions surge after White House promotion, leaving parents struggling to find the #drug at pharmacies. #WTFWire, #AutismAwareness, #AutismTreatment, #Leucovorin, #HealthcareNews, #MedicalNews, #PharmacyShortage, #DrugShortage, #PublicHealth
www.wtfwire.com/health/leuco...

FDA approves new use of synthetic vitamin B9 — but not for autism symptoms Federal officials touted leucovorin as a potential treatment for autism symptoms. But the FDA said there isn't data to approve it for that purpose.

Federal officials touted #leucovorin as a potential treatment for #autism symptoms. But the #FDA said there isn't data to approve it for that purpose.

What Is Leucovorin and How Does It Work How leucovorin works in cancer treatment and folate disease, and why doctors use it to protect healthy cells during therapy.

Leucovorin supports chemotherapy by protecting healthy cells and boosting treatment. Learn uses, dosage & side effects: www.yourhealthstyle.com/leucovorin/

#Leucovorin #Chemotherapy #CancerTreatment #CancerCare #HealthEducation

FDA approves leucovorin – but not for autism The FDA stops short of approving leucovorin for autism, but will its clearance for ultra-rare condition CFD-FOLR1 lead to more off-label prescribing?

The #FDA has approved the #generic drug #leucovorin as a treatment for an #ultrararecondition, with autism-like symptoms, known as #cerebralfolatedeficiency.

pharmaphorum.com/news/fda-app...

FDA contradicts Trump admin, declines to approve generic drug for autism https://arstechni.ca #leucovorin #Health #autism #makary #fda

FDA finds little evidence that a generic drug can help people with autism — The Associated Press The FDA is approving a generic drug for a very rare genetic disorder, but not for autism. On Tuesday, the U.S. agency said the drug helps children and adults who cannot get enough folate into the brai...

apple.news/A97yUBKovTHi...
#Leucovorin
-this form of vitamin folate has been approved & used for decades for effects of chemotherapy
-Despite APA contrary recommendations, FDA has approved it for an extremely rare mutation, CFD, which limits folate uptake
-Bobby & Oz have financial stake in it

TikTok - Make Your Day

Part 1 - Let's talk about Folic Acid!

Folate is also hot in the news due to methylation gene defects and it's relationship to Autism. Let's find out from @thekidsvitamindoctor!

#autism #leucovorin #diet #KidsHealthMatters #ParentLifeCanada #PaedsPatrolTips

vt.tiktok.com/ZSu1gCWSG/

The Leucovorin Question in Autism: What a Retraction Teaches Us About Evidence, Hope, and Clinical Humility A child psychiatrist's perspective on a shifting evidence base

A clinical trial just got retracted—wiping out 20% of the evidence for leucovorin in autism. The real story is what it reveals about hope, desperation, and how far we still have to go for these families.
#Autism #AutismResearch #ChildPsychiatry #Leucovorin

open.substack.com/pub/slaterj/...

Clinical trial supporting leucovorin for treating autism is retracted A clinical trial supporting leucovorin for autism treatment was retracted due to data errors and statistical concerns.

A clinical trial supporting #leucovorin for #autism treatment was retracted due to data errors and statistical concerns, raising doubts about its efficacy. Evidence for leucovorin's effectiveness in autism is limited.

Clinical trial supporting leucovorin for treating autism is retracted A clinical trial supporting leucovorin for autism treatment was retracted due to data errors and statistical concerns.

A clinical trial supporting #leucovorin for #autism treatment was retracted due to data errors and statistical concerns, raising doubts about its efficacy. Evidence for leucovorin's effectiveness in autism is limited. www.skepticalraptor.com/skepticalrap...

Retraction Note: Efficacy of oral folinic acid supplementation in children with autism spectrum disorder: a randomized double-blind, placebo-controlled trial - European Journal of Pediatrics European Journal of Pediatrics -

The Panda et al (2024) paper on leucovorin treatment for autism that we raised concern about in our PubPeer comment in September has been retracted.
#autism #leucovorin #folinicacid

link.springer.com/article/10.1...

Autism Claims for Leucovorin Race Ahead of the Science Messaging may fuel unproven autism treatment, doctors say

What we heard this week⬇️
"If a million people start using it for autism, not only are they using it for something that's unproven, but they're compromising its use for its proven uses." -Bruce Chabner, MD, warning against off-label use of #leucovorin for #autism.
www.medpagetoday.com/neurology/au...

#leucovorin is a medicine i will not take. They say its for #autism. But i could not find anything definitively and conclusively saying as such.It could help with autistic like symptoms but does not help Autism altogether. #Tylenol had research done and provide to not cause autism either. Its all BS

American Academy of Pediatrics Warns Parents Against Using Leucovorin for Autism Treatment, Citing Lack of Evidence and FDA Review

👉 NewsLink7.com

#Pediatrics #Autism #Therapy #Parents #Doctors #Grandparents #WhiteHouse #PressConference #September22 #FDA #Leucovorin #News #Noticias

Interim Guidance from the American Academy of Pediatrics: Use of Leucovorin in Autistic Pediatric Patients View Interim Guidance from the American Academy of Pediatrics: Use of Leucovorin in Autistic Pediatric Patients

Leucovorin for autism is BS, y'all: "At this time, the American Academy of Pediatrics @ameracadpeds.bsky.social (AAP) does not recommend the routine use of leucovorin (folinic acid) for autistic children."

www.aap.org/en/patient-c...

#autism #neurodiversity #leucovorin

My nonverbal daughter’s neurologist moved away. We’re now navigating waitlists just for a chance to try a medication that could help her find her voice. This is autism parent advocacy.

#Autism #Nonverbal #Parenting #leucovorin

Please visit the link below to read the SIMD board of directors's letter to U.S. Department of Health and Human Services (HHS), Secretary Kennedy regarding #autism and #cerebralfolatedeficiency and #leucovorin.

simd.org/wp-content/u...

Original post on mas.to

"For decades, the parents of #autistic children have been sold false hope by charlatans claiming their products could cure #autism. While the Trump administration is not making this claim, it has created confusion by changing #leucovorin’s label without rigorous testing as an autism treatment or […]

What real science says about leucovorin as an autism treatment? Trump and RFK Jr promoted leucovorin as a cure for autism. However, scientific evidence does not support its efficacy for autism.

Trump and RFK Jr promoted #leucovorin as a cure for #autism. However, scientific evidence does not support its efficacy for autism.

What real science says about leucovorin as an autism treatment? Trump and RFK Jr promoted leucovorin as a cure for autism. However, scientific evidence does not support its efficacy for autism.

Trump and RFK Jr promoted #leucovorin as a cure for #autism. However, scientific evidence does not support its efficacy for autism. www.skepticalraptor.com/skepticalrap...

Ava’s neurologist is researching Leucovorin to see if it could help her neurological symptoms. Every step forward matters—praying for answers and new hope for our girl. #HopeForAva #Leucovorin

FDA Says Leucovorin Can Help in Autism: Here's What to Know Evidence supporting the drug's use in autism patients is limited

"It's very dubious how many children are going to benefit from this treatment." -- @htagerf.bsky.social, of Boston University, also commenting on #leucovorin.
www.medpagetoday.com/neurology/au...

Does FDA's Leucovorin Decision Meet the Bar for Gold-Standard Science? Experts stunned by expected FDA approval based on scant data

What we heard this week ⬇️ #MedSky

"They are over their skis, saying this is a cure in the absence of anything that's remotely persuasive as evidence." -- Arthur Caplan, PhD, discussing Trump and his top health officials' promotion of #leucovorin for #autism.
www.medpagetoday.com/pediatrics/a...

What is the Difference Between Folate, Folic Acid, Folinic Acid, and Methylfolate? Learn the key differences between folate, folic acid, folinic acid, and methylfolate—how they impact health, metabolism, and MTHFR mutations.

The discussion re folinic vs folic acid has frequently come up, with some apparent confusion, ignoring the reductase issue, etc. Please distribute widely, as this is an excellent and very simple explanation of similarities and differences: #Leucovorin #Autism #HHS #Tylenol #Trump #Medsky #Pediatrics

bsky.app/profile/crys...

Trumps administration is the most corrupt in US history!

#iHerb #Oz #Kennedy #FolinicAcid #leucovorin

Will Dr Oz benefit from Trump's FDA approving Leucovorin? What to know The U.S. Food and Drug Administration approved the drug Monday to treat autism symptoms.

#Oz, a heart surgeon & celebrity doctor, invested in #iHerb, a #California supplement retailer that sells folinic acid, the supplement found in #leucovorin.

This link led people to claim Oz will profit from it being approved more widely & from its increased profile in the news. 🤔 (Trump says no)

What is leucovorin? Researchers mixed on Trump, RFK Jr.'s potential answer to autism Trump administration officials are expected to discuss a medication called leucovorin as a potential treatment for autism.

What is leucovorin?

#Leucovorin, also known as folinic acid, is a high-dose prescription. It now is prescribed to counteract the toxic effects #chemotherapy medications such as methotrexate. It's also used as a treatment for anemia.

A low dose of this folinic acid is ALSO sold by Dr. Oz. 😕

#iHerb

Leucovorin’s Potential in Autism Treatment Explored 🚨The Trump Administration has spotlighted leucovorin—a decades‑old chemotherapy support drug—as a potential autism treatment. Early studies show promise for some patients, but experts warn it may n…

Leucovorin: potential autism aid? Early promise but needs caution. 🧩 divinemagazine.biz/can-leucovor... #AutismAwareness #Leucovorin #HealthNews #AutismResearch #MedicalNews #Chemotherapy #Innovation #TrumpAdministration #Healthcare #ScienceNews