Trends in the minimum inhibitory concentrations for four agents against methicillin-resistant Staphylococcus aureus in bloodstream infections in China: a 6-year multi-center study from 2017 to 2022

This study of 3901 #StaphylococcusAureus blood isolates in #China shows rising vancomycin MICs and declining #linezolid MICs in #MRSA, revealing reduced #vancomycin sensitivity but improved linezolid response, with key implications for treatment. #Microbiology
#OpenAccess: doi.org/10.1016/j.dc...

One of these is cfr(B), which is increasingly seen in #cdiff. We showed for the first time a causal role for this gene in resistance to #PhLOPSa ##antibiotics, including #linezolid and #clindamycin.

Trends in the minimum inhibitory concentrations for four agents against methicillin-resistant Staphylococcus aureus in bloodstream infections in China: a 6-year multi-center study from 2017 to 2022

A multicenter China study shows #MRSA bloodstream isolates are becoming less sensitive to #vancomycin but more sensitive to #linezolid, while daptomycin and teicoplanin stay stable, highlighting shifting #antimicrobialsusceptibility.

#OpenAccess: doi.org/10.1016/j.dc...

Trends in the minimum inhibitory concentrations for four agents against methicillin-resistant Staphylococcus aureus in bloodstream infections in China: a 6-year multi-center study from 2017 to 2022

This multicenter study identified a significant longitudinal trend of decreased #Vancomycin sensitivity with improved #Linezolid susceptibility, providing critical regional insights into the evolving #AntibioticResistance landscape of #MRSA.
#OpenAccess: doi.org/10.1016/j.dc...

Trends in the minimum inhibitory concentrations for four agents against methicillin-resistant Staphylococcus aureus in bloodstream infections in China: a 6-year multi-center study from 2017 to 2022 Staphylococcus aureus bacteremia is a critical and pernicious infection, and in particular methicillin-resistant Staphylococcus aureus (MRSA) is incre…

Scientists track #MICs trends in #MRSA bloodstream isolates, showing declining #vancomycin susceptibility, improved #linezolid sensitivity and stable daptomycin/teicoplanin activity, underscoring the need for ongoing #antimicrobial surveillance.

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Although the exact mechanism of tooth discoloration with #linezolid is unknown, it differs from tetracycline-induced discoloration in that it is extrinsic and reversible

rare #linezolid induced #toothdiscoloration. Stains that are present on outer surface of teeth & can be removed manually are known as extrinsic stains, vs. stains that are deposited within the enamel during tooth development are known as intrinsic stains

#idsky #neurosky #idcrit

#MRSA/#MRSE CNS infection not responding to IV #Vancomycin, follow @idsainfo.bsky.social ‘17 guidelines & begin intrathecal/intraventricular vanc, or switch to #linezolid?

@bradspellberg.bsky.social @mbrigmon.bsky.social @pulmcrit.bsky.social @idvilchez.bsky.social

Read the Journal of #Infection for the study assessing the effectiveness of #bedaquiline, #pretomanid and #linezolid regimens with varying doses and duration of #linezolid at the end of 48 weeks post treatment among drug resistant #tuberculosis patients 👉 www.journalofinfecti...

#SDG3 #SepticShock #Linezolid

@cindyclau.bsky.social but what about increased linezolid doses???
#DDIs, #obesity ???
Some case studies in patients with respiratory infections/ ARDS suggest different oxidative pathways and up regulation of CYP expression that may influence #linezolid concentrations #antimicrobials2025

@cindyclau.bsky.social
#linezolid does one dose fit all????
Most likely not! Dr Cindy Lau goes through some scenarios - elderly, renal and hepatic impairment, #DDIs - where dose reductions may be warranted to improve patient care (& reduce toxicities)
#antimicrobials2025 #IDsky #amssky

Advocating for linezolid TDM to improve patient outcomes 😊#Antimicrobials2025 #ASA2025 #linezolid #TDM @lisaparadiso.bsky.social

Seems the perfect first post and start to Antimicrobials 2025; thank you to the brilliant @erinmccreary.bsky.social for a great opening plenary (but please get out of my head 😉) #linezolid #cefepime