Well explained @plosbiology.org , understanding HCT and its transcriptional control opens doors for regenerative liver science.
Stay updated with more such studies on SciOpen: www.sciopen.com

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🎉 Thrilled to share that I’ve been appointed as the new national Science Lead for the British Association for the Study of the #Liver 🎉

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Hepatic stellate cells control liver zonation, size and functions via R-spondin 3 | Nature Hepatic stellate cells (HSCs) have a central pathogenetic role in the development of liver fibrosis. However, their fibrosis-independent and homeostatic functions remain poorly understood1–5. Here we demonstrate that genetic depletion of HSCs changes WNT activity and zonation of hepatocytes, leading to marked alterations in liver regeneration, cytochrome P450 metabolism and injury. We identify R-spondin 3 (RSPO3), an HSC-enriched modulator of WNT signalling, as responsible for these hepatocyte-regulatory effects of HSCs. HSC-selective deletion of Rspo3 phenocopies the effects of HSC depletion on hepatocyte gene expression, zonation, liver size, regeneration and cytochrome P450-mediated detoxification, and exacerbates alcohol-associated and metabolic dysfunction-associated steatotic liver disease. RSPO3 expression decreases with HSC activation and is inversely associated with outcomes in patients with alcohol-associated and metabolic dysfunction-associated steatotic liver disease. These

Hepatic stellate cells and RSPO3 are key in liver zonation and size via WNT changes. Impact seen in regeneration and metabolism. #LiverScience PMID:40074890, Nature 2025, @Nature https://doi.org/10.1038/s41586-025-08677-w #Medsky #Pharmsky #RNA 🧪

🧬 Exciting discovery! 🧬 oxLDL disrupts liver cell ultrastructure (sieve plates, fenestrations) but cells remain viable and keep scavenging function! 💪 New insights into liver resilience under oxLDL stress! 🌟 #Endothelium #LiverScience
🔗 DOI: 10.1038/s44355-024-00009-5

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