Roles of the lamin A-specific tail region in the localization to sites of nuclear envelope rupture Abstract. The nuclear lamina (NL) lines the nuclear envelope (NE) to maintain nuclear structure in metazoan cells. The major NL components, the nuclear lam

Roles of the #Lamin A-specific Tail Region in the Localization to Sites of Nuclear Envelope Rupture @PNASNexus.org
@sciencetokyo.bsky.social #KanazawaUniv #NanoLSI
#Progeria #HGPS #RareDisease #Lonafarnib #Zokinvy #Laminopathy #cardiomyopathy #lipodystrophy #LMNA academic.oup.com/pnasnexus/ar...

#HDV virological response not augmented by addition of #lonafarnib to alpha-IFN though ALT normalization significantly higher in lonafarnib arms. Significance unknown. @EASLnews @EASLedu #EASLCongress

Is #lonafarnib a viable option for #HDV infection? Hard to say based on D-LIVER study results. Efficacy data below. 20% discontinued, no breakdown of AE etiology but “mostly GI side effects”
#EASLCongress @EASLnews @EASLedu

Eiger Announces Both #lonafarnib based Treatments in Pivotal Phase 3 D-LIVR Trial in Hepatitis Delta Virus #HDV Achieved Statistical Significance Against Placebo in Composite Primary Endpoint...