Genotype-specific differences in infertile men due to loss-of-function variants in #M1AP or ZZS genes

By @nadjarotte.bsky.social ‬, @corinnafriedrich.bsky.social at Institute of Reproductive Genetics @uni-muenster.de

👉 doi.org/10.1038/s443...

Genotype-specific differences in infertile men due to loss-of-function variants in M1AP or ZZS genes | EMBO Molecular Medicine imageimageOne cause of male infertility is meiotic arrest and azoospermia. This condition can be caused by variants in M1AP or the ZZS complex components SHOC1, TEX11, and SPO16, which play a role in ...

Our study on #human #M1AP as a non-essential but functional enhancer of
ZZS-mediated homologous #recombination has just been published in
@embomolmed.org! So excited for you to dive into our work:
www.embopress.org/doi/full/10..... What a great
collaborative effort!

Genotype-specific differences in infertile men due to loss-of-function variants in M1AP or ZZS genes | EMBO Molecular Medicine imageimageOne cause of male infertility is meiotic arrest and azoospermia. This condition can be caused by variants in M1AP or the ZZS complex components SHOC1, TEX11, and SPO16, which play a role in meiotic recombination. This study provides ...

Excited to share our new study @embomolmed.org! LoF #variants in the #meiosis genes #M1AP or TEX11, SHOC1, SPO16 (ZZS) cause different arrests in sperm development. And yes – M1AP-deficient men can father healthy children via MAR! Dive into the whole story here: www.embopress.org/doi/full/10.....

Great talk @SaraPersio ! Since we identified #cryptozoospermic men in our #M1AP project too, these are definitely some interesting findings.

x.com/SandLaurentino…