#METABRIC

Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity - Nature NMDAR expression is sufficient to induce B cell recruitment and affinity maturation, resulting in receptor-modulating antibodies that connect anti-cancer immunity and autoimmunity.

Amazing from Tobias Janowitz and co from @cshlnews.bsky.social published @nature.com!
Great also to see yet another major piece of #BreastCancer research using #METABRIC!!

www.nature.com/articles/s41...

Imaging mass cytometry and multiplatform genomics define the phenogenomic landscape of breast cancer - Nature Cancer Bodenmiller and colleagues pair imaging mass cytometry with data from the METABRIC cohort to define single-cell phenotypic and genomic features of breast cancer with spatial context, finding associati...

Impactful and pioneering work! Now cited 200 times! A new paradigm: phenogenomic landscapes in cancer. @hrazaalilab.bsky.social @bb-lab.bsky.social @caldaslab.bsky.social
#METABRIC
We were walking the walk on multi-omics already in 2020!!

www.nature.com/articles/s43...

Breast tumor microenvironment structures are associated with genomic features and clinical outcome - Nature Genetics Imaging mass cytometry profiling of 693 breast tumors identified 10 recurrent tumor microenvironment spatial structures. These structures were enriched in different molecular subtypes and can be assoc...

The above reused the data from #METABRIC published in 2022 @natureportfolio.nature.com👇

www.nature.com/articles/s41...

Temporal tissue dynamics from a spatial snapshot - Nature One-shot tissue dynamics reconstruction can infer changes in tissue composition over time, from single-time-point spatial proteomics of human cancers.

www.nature.com/articles/s41...
Once more #METABRIC continues to enable major discoveries! @urialonlab.bsky.social used our data to do this 👇

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups - Nature Integrative analysis of copy number and gene expression in 2,000 primary breast tumours with long-term clinical follow-up revealed putative cis-acting driver genes, novel subgroups and trans-acting ab...

#METABRIC marker paper now cited >4,500 times!!!
Wow! @caldaslab.bsky.social celebrates 🥳💯💥💫 this landmark!
Walking the walk for decades!!
@ims-mrl.bsky.social
@lautenbergc.bsky.social
@hebrewuniversity.bsky.social

www.nature.com/articles/nat...

Fantastic work by @kevinjtu.bsky.social done as MSc @caldaslab.bsky.social in collaboration with @ruedalab.bsky.social and @stephensammut.bsky.social. #TME deconvolution in 15,000 breast cancers! #METABRIC
@ims-mrl.bsky.social @hebrewuniversity.bsky.social @lautenbergc.bsky.social
🥳🥳👍👍💪💪

snDNAseq of 40,000 cells from 140 tumors from #METABRIC. @mauriziocallari.bsky.social and @sc10021.bsky.social will soon write a major papers from this work! @caldaslab.bsky.social continues to produce outstanding science!

#METABRIC!!

#METABRIC was again used to validate findings in the clinical setting!

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups - Nature Integrative analysis of copy number and gene expression in 2,000 primary breast tumours with long-term clinical follow-up revealed putative cis-acting driver genes, novel subgroups and trans-acting ab...

#METABRIC 13 years later: redefined breast cancer! Cited 4,300 times and still counting! @caldaslab.bsky.social celebrates a milestone!

www.nature.com/articles/nat...

I would have never had the career I have had if it was not for Ian Ellis! He is in nearly all of my major papers. #METABRIC is in great part thanks to him! @caldaslab.bsky.social celebrates an amazing breast pathologist and unique colleague! Thank you, Ian!!

youtu.be/tft8ass_IZs?...

Age-associated microenvironmental changes highlight the role of PDGF-C in ER+ breast cancer metastatic relapse - Nature Cancer Turrell et al. show that, in young mice, low-level PDGF-C expression maintains dormancy of disseminated tumor cells, but, in aged or fibrotic lungs, the PDGF-C-high environment promotes proliferation,...

#METABRIC continues to have enormous impact: here to validate findings from murine study of novel metastasis biology!
@caldaslab.bsky.social is very proud!

www.nature.com/articles/s43...

New data tool could bring RNA sequencing into standard clinical practice, improving diagnosis and treatment New data tool could bring RNA sequencing into standard clinical practice, improving diagnosis and treatment

Important translational piece from @icrlondon.bsky.social and Brisken lab. Yet again #METABRIC being used to develop/validate tool! @caldaslab.bsky.social research continues to have huge impact! Walking the walk!

www.icr.ac.uk/about-us/icr...

Just finished a Teams meeting with @mauriziocallari.bsky.social and Oscar Rueda discussing Single Nucleus Sequencing generated by @sc10021.bsky.social from 150 #METABRIC breast cancers, in conjunction with all the other multi-omic data. At #EACR2025 update coming...

Molecular characterization of HER2-negative breast cancers reveals a distinct patient subgroup with 17q12 deletion and heterozygous loss of ERBB2 The approval of trastuzumab deruxtecan has prompted the subgrouping of human epidermal growth factor receptor 2-negative (HER2−) breast cancers (BCs) to HER2 0 and HER2 low on the basis of immunohisto...

#METABRIC again and again! Seminal contribution from @caldaslab.bsky.social used to make new discoveries 13 years later!
Walking the walk!!!

www.esmoopen.com/article/S205...