The Minimal Model of Resonance Dynamics (MMRD): Structural Singularization and Critical Stability Thresholds in Complex Adaptive Networks This preprint introduces the Minimal Model of Resonance Dynamics (MMRD), a theoretical framework for analyzing systemic fragility and critical transitions in complex adaptive systems. The model formal...

Most systemic crises are not caused by chaos, but by excessive structural optimization.

The #MMRD framework derives a critical stability threshold for resonance-driven collapse in complex adaptive networks.

doi.org/10.5281/zeno... 🖖

The Minimal Model of Resonance Dynamics (MMRD): Structural Singularization and Critical Stability Thresholds in Complex Adaptive Networks This preprint introduces the Minimal Model of Resonance Dynamics (MMRD), a theoretical framework for analyzing systemic fragility and critical transitions in complex adaptive systems. The model formal...

Complex systems rarely collapse because of chaos …

they collapse when efficiency erodes structural diversity.

My newPreprint introduces the #MinimalModelOfResonanceDynamics #MMRD & derives a critical stability threshold for systemic collapse in complex adaptive networks. doi.org/10.5281/zeno... 🖖

ctDNA after surgery for MMRd tumors can prevent cancer recurrence - Yelena Janjigian at AACR25 - OncoDaily Yelena Janjigian presents new clinical trial findings at AACR 2025 showing that ctDNA testing after cancer surgery can guide personalized immunotherapy and help prevent recurrence.

ctDNA after surgery for MMRd tumors can prevent cancer recurrence – Yelena Janjigian at AACR25

@mskcancercenter.bsky.social @theaacr.bsky.social

oncodaily.com/insight/yele...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #AACR25 #AACR2025 #MMRd #CancerRecurrence #ctDNA

Long deletion signatures in repetitive genomic regions track somatic evolution and enable sensitive detection of microsatellite instability Deficiency in the mismatch repair system (MMRd) causes microsatellite instability (MSI) in cancers and determines eligibility for immunotherapy. Here, we show that MMRd tumours harbour long-deletion s...

Thrilled to share our discovery of novel long-deletion signatures—key markers for tracking #MMRd #CancerEvolution, even in low-pass (~0.1X) FFPE samples with low purity. This was made possible with our tool, MILO, as named by @trevorgraham.bsky.social. Our preprint: www.biorxiv.org/content/10.1...

PACSCL is delighted to have been a test site for the #MMRD model created by @StephanieMLuke & Sharon Mizota.

Read their article at link.springer.com/epdf/10.1007...